黄曲霉毒素B1诱导的活性玫瑰花结形成抑制的可复性研究  

REVERSIBILITY OF AFLATOXIN B1 INHIBITED ACTIVE ROSETTE FORMATION

作　　者：刘玉欣[1] 余新生[1] 杨瑶琴[1] 周学优 

机构地区：[1]上海市肿瘤研究所

出　　处：《肿瘤》1983年第1期13-14,46-47,共4页Tumor

摘　　要：文献上已经有许多探讨黄曲霉毒素B1(AFB1)对免疫系统作用的报道,为AFB1引起肝细胞癌的作用机制增添了新的见解。AFB1除了作为癌的直接病因外.Reversibility of aflatoxin Binhibited active rosette formation(Ea)of the peripheralblood lymphocytes from healthy human individuals and from patients with hepatic carcinoma was studied.In vitro,aflatoxin Binhibited Ea formation of lymphocytes andsheep red blood cells.When aflatoxin Bwas washed off,the lymphocytes,keeping at 4℃,still 1ost their Ea capacity.When incubated at 37℃,however,thelymphocytes from healthypersons regained the Ea capacity and Ea percentage rose to the usual level;while thoseIymphocytes from patients with hepatic carcinoma remained inert.These results indicatethat the lymphocytes of health individuals,treated with a limited amount of aflatoxin Bfor a short time,followed by washing off,can restore their functional activity,,but thatof the lymohocytes of the patients with hepatic carcinoma cannot be restored.

关 键 词：淋巴细胞 AFB 正常人 白细胞 黄曲霉毒素 可复性 B1 

分 类 号：TS2[轻工技术与工程—食品科学与工程]