氟哌噻吨美利曲辛与舍曲林二联疗法治疗脑梗死后情绪障碍患者的疗效及对汉密尔顿抑郁量表评分、神经功能缺损评分及美国国立卫生院神经功能缺损评分的影响  

Effects of Haloperthiazine Combined with Sertraline on the Patients with Post-Infarction Mood Disorders and its Effects on Hamilton Depression Scale Score(HAMD),Neurological Function Defect Score(NFDS),and the National Health Institutes of Neurological Deficit Scores

作　　者：李芳[1] 赵林岩[2] 蔺建文[1] 赵红玲[1] 王晓东[3] LI Fang;ZHAO Lin-Yan;LIN Jian-Wen;ZHAO Hong-Ling;WANG Xiao-Dong(The First Department of Neurology,Dalian Central Hospital,Dalian 116021,China;Severe Medicine Department of the Second Affiliated Hospital of Dalian Medical University,Dalian 116027,China;The Stroke Ward of Dalian Central Hospital,Dalian 116021,China)

机构地区：[1]大连市中心医院神经内一科,辽宁大连116021 [2]大连医科大学附属第二医院重症医学科,辽宁大连116027 [3]大连市中心医院脑卒中病房,辽宁大连116021

出　　处：《中国药物经济学》2020年第2期118-121,共4页China Journal of Pharmaceutical Economics

摘　　要：目的探讨氟哌噻吨美利曲辛与舍曲林二联疗法治疗脑梗死后情绪障碍患者的疗效及对汉密尔顿抑郁量表(HAMD)评分、神经功能缺损评分(NFDS)及美国国立卫生院神经功能缺损评分(NHISS)的影响。方法选取2017年1月至2019年1月大连市中心医院收治的脑梗死后情绪障碍患者60例作为研究对象,以随机数字表法将其分为单一组和二联组。单一组予以舍曲林治疗,二联组则予以氟哌噻吨美利曲辛与舍曲林二联疗法治疗,比较两组治疗前后HAMD、NFDS及NHISS评分变化情况,血清5-羟色胺(5-HT)、多巴胺(AD)、去甲肾上腺素(NE)水平,不良反应发生情况。结果二联组及单一组治疗后HAMD评分均得到显著改善,且二联组改善程度显著优于单一组(P<0.05)。二联组及单一组治疗后NFDS、NHISS评分均得到显著改善,且二联组改善程度显著优于单一组(P<0.05)。治疗后,二联组与单一组5-HT、DA、NE水平显著高于治疗前,且二联组5-HT、DA、NE水平显著高于单一组。二联组及单一组胃肠道反应、食欲下降、大便干结以及震颤发生率比较,差异无统计学意义(P>0.05)。结论氟哌噻吨美利曲辛与舍曲林二联疗法治疗脑梗死后情绪障碍疗效显著,有利于改善患者抑郁状态,提高神经功能,且安全性较好。Objective To exlpore the effects of haloperthiazine combined with sertraline on the patients with post-infarction mood disorders and its effects on Hamilton Depression Scale Score(HAMD),Neurological Function Defect Score(NFDS),and the National Health Institutes of Neurological Deficit Scores.Methods A total of 60 patients with mood disorders after cerebral infarction admitted to Dalian Central Hospital from January 2017 to January 2019 were included in the study,and they were divided into binary group and single group by random number table.The single group was treated with sertraline,while the binary group was treated with haloperthiazine combined with sertraline.Changes in HAMD,NFDS,and NHISS scores,and the levels of serum 5-HT(5-HT),dopamine(AD)and norepinephrine(NE)before and after treatment were compared between the 2 groups.Adverse reactions occurred.Results HAMD scores of the 2 groups and single group were significantly improved after treatment,and the improvement degree of the binary group was significantly better than the single group(P<0.05).NFDS and NHISS scores in both the binary group and the single group were significantly improved after treatment,and the degree of improvement in the binary group and single group was significantly better than the single group(P<0.05).After treatment,5-HT,DA and NE levels of the binary group and was significantly higher than the single group than those before treatment(P<0.05).5-HT,DA and NE l levels of the binary group were significantly higher than the single group.There was no significant difference between the binary group and the single group in the incidence of gastrointestinal reactions,appetite loss,dry stool and tremor(all P>0.05).Conclusion Haloperthiazine meritoxin combined with sertraline in the treatment of mood disorders after cerebral infarction has a significant effects,which is conducive to improving neurological function and has higher safety.

关 键 词：脑梗死 情绪障碍 氟哌噻吨美利曲辛 舍曲林 汉密尔顿抑郁量表 神经功能缺损评分 

分 类 号：R743.33[医药卫生—神经病学与精神病学]