拉坦前列腺素联合甲钴胺治疗原发性开角型青光眼的疗效探讨  被引量:1

Curative Effect Discussion of Latanoprost Combined with Mecobalamin in Treatment of Primary Open-angle Glaucoma

在线阅读下载全文

作  者:赵昌涛 ZHAO Changtao(Sishui County People's Hospital,Jining,Shandong,273200)

机构地区:[1]泗水县人民医院,山东济宁273200

出  处:《智慧健康》2022年第24期221-224,229,共5页Smart Healthcare

摘  要:目的探讨拉坦前列腺素联合甲钴胺治疗原发性开角型青光眼患者的临床疗效。方法选择泗水县人民医院于2018年1月-2020年1月期间收治的原发性开角型青光眼患者102例作为研究资料,随机数字抽签分为两组各51例,对照组行拉坦前列腺素治疗,观察组采取拉坦前列腺素联合甲钴胺治疗,测定治疗前、治疗后两组眼压、视野缺损及视网膜纤维层厚度变化,评价两组临床疗效,观察用药后不良反应发生情况。结果治疗前两组眼压、视野缺损及视网膜纤维层厚度比较无统计学意义(P>0.05);治疗后,两组患者白天眼压、夜间眼压、眼压波动值显著降低,观察组眼压显著低于对照组(P<0.05)。治疗后,两组上方视野、下方视野、鼻侧视野、颞侧视野的视野缺损显著降低,而且观察组视野缺损显著低于对照组(P<0.05)。治疗后,观察组上方视盘、下方视盘、鼻侧视盘、颞侧视盘的视网膜纤维层厚度提高,而且观察组视网膜纤维层厚度显著高于对照组(P<0.05)。观察组治疗有效率96.08%高于对照组80.39%,比较有统计学意义(P<0.05)。观察组心率加快、心律不齐、呼吸急促等不良反应发生率3.92%、1.96%、5.88%与对照组5.88%、3.92%、3.92%比较无统计学意义(P>0.05)。结论针对原发性开角型青光眼患者行拉坦前列腺素联合甲钴胺治疗可促使症状消除,进一步降低并稳定眼压,改善视野缺损,增加视网膜纤维层厚度,获得良好的疗效,而且不会增加不良反应,值得推广。Objective To investigate clinical effect of latanoprost combined with mecobalamin in treatment of primary open-angle glaucoma.Methods The paper chose 102 patients with primary open-angle glaucoma treated in Sishui County People’s Hospital from January 2018 to January 2020 as research data,and divided them into two groups randomly,with 51 cases in each group.Control group was treated with latanoprost,and observation group with latanoprost combined with mecobalamin.Changes of intraocular pressure,visual field defect and retinal fiber layer thickness between two groups before and after treatment were measured,clinical effect between two groups was evaluated,adverse reactions after medication was observed.Results There was no significant difference in intraocular pressure,visual field defect and retinal fiber layer thickness between two groups before treatment,(P>0.05);After treatment,intraocular pressure during the day,at night and fluctuation of intraocular pressure between two groups decreased significantly,and intraocular pressure in observation group was significantly lower than control group,(P<0.05).After treatment,visual field defects of upper visual field,lower visual field,nasal visual field and temporal visual field between two groups were significantly reduced,visual field defects in observation group were significantly lower than control group,(P<0.05).After treatment,thickness of retinal fiber layer of upper optic disc,lower optic disc,nasal optic disc and temporal optic disc in observation group increased,thickness of retinal fiber layer in observation group was significantly higher than control group,(P<0.05).Effective rate of observation group was 96.08%,higher than control group(80.39%),with statistical significance,(P<0.05).Incidence of adverse reactions including rapid heart rate,arrhythmia and shortness of breath in observation group was 3.92%,1.96%and 5.88%,which was not statistically significant compared with 5.88%,3.92%and 3.92%in control group(P>0.05).Conclusion Latanoprost combined with me

关 键 词:拉坦前列腺素 甲钴胺 原发性开角型青光眼 临床疗效 不良反应 

分 类 号:R775.2[医药卫生—眼科]

 

参考文献:

正在载入数据...

 

二级参考文献:

正在载入数据...

 

耦合文献:

正在载入数据...

 

引证文献:

正在载入数据...

 

二级引证文献:

正在载入数据...

 

同被引文献:

正在载入数据...

 

相关期刊文献:

正在载入数据...

相关的主题
相关的作者对象
相关的机构对象