急性淋巴细胞性白血病患儿化疗期间营养状况与化疗并发症的相关性研究  

Study on the Relationship Between Nutritional Status and Chemotherapy Complications in Children with Acute Lymphoblastic Leukemia During Chemotherapy

作　　者：胡艳君 孟江南[1] HU Yan-jun;MENG Jiang-nan(Nanfang Hospital,Southern Medical University,Guangzhou,Guangdong 510515)

机构地区：[1]南方医科大学南方医院儿科,广东广州510515

出　　处：《智慧健康》2022年第22期102-104,109,共4页Smart Healthcare

摘　　要：目的探讨急性淋巴细胞性白血病(ALL)患儿化疗期间营养状况与化疗并发症的相关性。方法选择2021年1~6月在南方医科大学南方医院化疗的60例ALL患儿为研究对象,评估患儿化疗期间营养状况分为营养不良组10例、营养正常组36例和营养过剩组14例。分析不同营养状况患儿化疗并发症发生情况及两者相关性。结果三组粒细胞缺乏率均为100.00%,营养不良组感染率高于营养正常组、营养过剩组,差异有统计学意义(P<0.05),营养不良组肝损伤率略高于营养正常组、营养过剩组,差异无统计学意义(P>0.05);营养正常组与营养过剩组感染、肝损伤发生率比较,差异无统计学意义(P>0.05);营养不良组粒细胞缺乏持续时间为(11.62±3.24)d,长于营养正常组的(6.62±2.14)d与营养过剩组的(7.01±2.30)d,差异有统计学意义(P<0.05);营养正常组与营养过剩组粒细胞缺乏持续时间比较,差异无统计学意义(P>0.05);营养状况与感染、粒细胞缺乏持续时间呈负相关(r=-0.317、-0.284,P<0.05);营养状况与肝损伤发生率无相关性(r=-0.199,P>0.05)。结论ALL患儿化疗期间营养状况与感染发生、粒细胞缺乏持续时间密切相关。Objective To investigate the correlation between nutritional status and chemotherapy complications in children with acute lymphoblastic leukemia(ALL)during chemotherapy.Methods Sixty children with ALL who received chemotherapy in our hospital from January 2021 to June 2021 were selected as the research objects.The nutritional status of the children during chemotherapy was assessed and they were divided into 10 cases of malnutrition group,36 cases of normal nutrition group and 14 cases of overnutrition group.The incidence of chemotherapy complications in children with different nutritional status and their correlation were analyzed.Results The rates of agranulocytosis in the three groups were all 100.00%.The infection rate of the malnutrition group was higher than that of the normal nutrition group and the overnutrition group,and the difference was statistically significant(P<0.05);The liver injury rate of the malnutrition group was slightly higher than that of the normal nutrition group and the overnutrition group,and the difference was not statistically significant(P>0.05);There was no significant difference in the incidence of infection and liver injury between the normal nutrition group and the overnutrition group(P>0.05);The duration of agranulocytosis in the malnutrition group was(11.62±3.24)days,which was longer than(6.62±2.14)days in the normal nutrition group and(7.01±2.30)days in the overnutrition group,and the difference was statistically significant(P<0.05);There was no statistically significant difference in the duration of agranulocytosis between the normal nutrition group and the overnutrition group(P>0.05);Nutritional status was negatively correlated with the duration of infection and agranulocytosis(r=-0.317,-0.284,P<0.05);nutritional status was not correlated with the incidence of liver injury(r=-0.199,P>0.05).Conclusion The nutritional status of ALL children during chemotherapy is closely related to the occurrence of infection and the duration of agranulocytosis.

关 键 词：急性淋巴细胞性白血病 营养状况 化疗并发症 

分 类 号：R733.71[医药卫生—肿瘤]