234例直径>5cm周围型非小细胞肺癌淋巴结转移情况研究  

Lymph Node Metastasis in 234 Patients with> 5cm Diameter Peripheral Non-small Cell Lung Cancer

作　　者：沈涛[1] 卢珠明[1] 段楚骁 张东熙 叶敏[1] 林志潮[1] SHEN Tao;LU Zhu-ming;DUAN Chu-xiao;ZHANG Dong-xi;YE Min;LIN Zhi-chao(Jiangmen Central Hospital(Affiliated Jiangmen Hospital of Sun Yat⁃sen University),Jiangmen,Guangdong 529030)

机构地区：[1]江门市中心医院/中山大学附属江门医院胸外科,广东江门529030

出　　处：《智慧健康》2022年第1期75-77,81,共4页Smart Healthcare

基　　金：江门市医疗卫生领域科技计划项目,项目名称:非小细胞肺癌淋巴结转移规律的临床研究,立项编码:2018A027

摘　　要：目的探讨直径>5cm周围型非小细胞肺癌淋巴结转移情况。方法本次回顾性研究我科2015年至2019年收治直径>5cm周围型非小细胞肺癌患者234例,分析肺癌淋巴结转移与不同病理类型,年龄、吸烟史、肿瘤直径、肿瘤与所在肺叶位置的关系。结果直径>5cm周围型非小细胞肺癌中,肺鳞癌与肺腺癌在性别、年龄和吸烟史方面均有统计学差异(P<0.05)。肺鳞癌相较肺腺癌,其发生年龄高,肿瘤直径大并多有吸烟史。肺鳞癌,N2淋巴结转移患者肿瘤直径较N2未转移组大,并多有吸烟史,且有统计学差异;肺腺癌,N2淋巴结转移患者肿瘤直径、吸烟史与N2未转移组无统计学差异;肺癌中壁层胸膜受侵情况,N2淋巴结是否转移,均无统计学差异。肺鳞癌中第10组淋巴结转移率最高,10.20%,第11组和第7组淋巴结转移率为8.53%和6.82%。肺腺癌第5组淋巴结转移率最高为26.58%,第7组淋巴结转移率为13.71%。结论直径>5cm周围型非小细胞肺癌中,上肺鳞癌应注意N2淋巴结跳跃式转移,肺鳞癌N2淋巴结转移与年龄、肿瘤直径,吸烟史有关,肺腺癌易出现N2淋巴结转移并与肿瘤位置无关;壁层胸膜侵犯与N2淋巴结转移无密切相关。Objective To investigate the lymph node metastasis of non-small cell lung carcinoma.Methods To studied 234 patients with>5 cm peripheral non-small cell lung cancer of diameter 5 from 2015 to 2019,and analyzed the relationship between lymph node metastasis of lung cancer,age,smoking history,tumor diameter,tumor and location of lung lobe.Results The squamous lung had a sex,age and smoking difference in lung adenocarcinoma history(P<0.05).Compared with lung adenocarcinoma,lung squamous carcinoma has a high age,large tumor diameter and a long history of smoking.Lung squamous carcinoma,N2 lymph node metastasis tumor diameter is larger than N2 nonmetastasis group,more smoking history,statistical difference,smoking diameter and N2 unmetastatic patients,lung cancer wall pleural invasion,N2 lymph node metastasis,no statistical difference.The lymph node metastasis rate was the highest in group 10,10.20%in lung squamous carcinoma,and 8.53%and 6.82%in group 11 and 7.The highest lymph node metastasis rate in group 5 and 13.71%in group 7.Conclusion In non-small cell lung carcinoma with>5cm,upper lung squamous carcinoma should pay attention to N2 lymph node skipping metastasis,lung squamous node metastasis is related to age,tumor diameter,smoking history,lung adenocarcinoma is prone to N2 lymph node metastasis and independent of tumor location;wall pleural invasion is not closely related to N2 lymph node metastasis.

关 键 词：非小细胞肺癌 淋巴结转移 N2淋巴结转移 

分 类 号：R734.2[医药卫生—肿瘤]