小剂量喹硫平联合阿立哌唑治疗老年期首发精神分裂症的疗效和安全性分析  

Effect and Safety Analysis of Low-dose Quetiapine Combined with Aripiprazole in Treatment of Elderly First-episode Schizophrenia

作　　者：闫冬惠 岳远聘 李俊红 YAN Dong-hui;YUE Yuan-ping;LI Jun-hong(Liaocheng City the Fourth People's Hospital,Liaocheng,Shandong,252000)

机构地区：[1]聊城市第四人民医院,山东聊城252000

出　　处：《智慧健康》2020年第21期45-47,共3页Smart Healthcare

摘　　要：目的分析老年期首发精神分裂症患者以小剂量喹硫平、阿立哌唑联合治疗的临床疗效和安全性。方法运用随机数表法将2018年3月至2019年5月从我院选取的老年期首发精神分裂症共计120例分为对照组和观察组,各60例,对照组单独应用阿立哌唑实施治疗,观察组联合应用阿立哌唑、小剂量喹硫平治疗,将临床疗效、阳性与阴性症状量表(PANSS)评分以及不良反应发生情况作为组间评价指标。结果各组分别在实施治疗措施后,观察组治疗总有效率为91.67%,痊愈、显著进步、进步、无效病例数分别为20/20/15/5例,显著高于对照组(76.67%)(P<0.05);治疗前两组患者PANSS评分中阳性症状、阴性症状、一般精神病理以及总分组均无显著差异(P>0.05),治疗后两组患者PANSS评分中阳性症状、阴性症状、一般精神病理以及总分均降低,且观察组低于对照组,组间差异显著(P<0.05);在对照组与观察组之间,不良反应发生率分别为38.33%、53.33%,无显著差异(P>0.05)。结论老年期首发精神分裂症经小剂量喹硫平联合阿立哌唑治疗取得了突出的临床效果,同时改善了患者的临床症状,具备较高的安全性,值得临床应用与借鉴。Objective To analyze clinical effect and safety of low-dose quetiapine combined with aripiprazole for elderly patients with first-episode schizophrenia.Methods With random number table method,choose 120 cases elderly first-episode schizophrenia in our hospital from March 2018 to May 2019,divide them into control group and observation group,60 cases in each.Control group was treated with piperazole,and observation group with aripiprazole and low-dose quetiapine.Evaluate clinical effect,positive and negative symptom scale(PANSS)scores,and adverse reactions incidence between groups.Results After treatment,total effective rate in observation group was 91.67%,and numbers of being cured,significantly improved,progressive,and invalid cases were 20/20/15/5 cases,significantly higher than control group(76.67%),(P<0.05);PANSS scores of positive symptoms,negative symptoms,general psychopathology,and general grouping showed no significant differences between two groups before treatment(P>0.05).PANSS scores of positive symptoms and negative symptoms,general psychopathology and total scores were reduced after treatment,and those of observation group were lower than control group,difference between groups was significant(P<0.05);incidence of adverse reactions of control group and observation group was 38.33%,53.33%,no significant difference(P>0.05).Conclusion Low-dose quetiapine combined with aripiprazole can achieve outstanding clinical results for elderly first-episode schizophrenia,at the same time,improve clinical symptoms of patients with high safety,which is worthy of clinical application and reference.

关 键 词：小剂量喹硫平 阿立哌唑 老年期首发精神分裂症 安全性 

分 类 号：R749.3[医药卫生—神经病学与精神病学]