驱钩新化合物三苯双脒的诱变性和致畸性检测  

MUTAGENICITY AND TERATOGENICITY TESTS ON ANTHELMINTIC AGENT TRIBENDIMIDIN

作　　者：邵葆若[1,2] 湛崇清 徐月琴 哈淑华[1,2] 

机构地区：[1]中国预防医学科学院寄生虫病研究所,上海 [2]世界卫生组织疟疾、血吸虫病、丝虫病合作中心

出　　处：《医药工业》1988年第3期112-115,共4页

摘　　要：驱钩新化合物王苯双脒(Tribendimidin)用鼠伤寒沙门氏菌/微粒体酶系统检测,对TA 97,TA98,TA 100及TA 102菌株未见诱变性。小鼠ig 500 mg/kg后24 h的骨髓微核试验结果为阴性,未见染色体畸变。培养的中国仓鼠肺成纤维细胞系的染色体畸变试验也为阴性。孕大鼠于d 8~d 10每日ig 200 mg/kg,未见有胚胎毒性及致畸性。A new broad-spectrum anthelmintic agent tribendimidin wasstudied for its mutagenicity and teratogenicity.No mutagenic effect was obser-ved by the following three tests:Salmonella/microsome system with TA 97,TA 98,TA100 and TA 102;micronucleus test in NIH mice administered up to500 mg/kg(about 1/2 LD50);in vitro chromosomal aberration test with Chinesehamster lung fibroblast cell line.No evidence of external and internal malfor-mations and skeletal deformities were observed in pregnant rats administeredorally up to daily dose of 200 mg/kg from d8 to d10 of gestation.

关 键 词：抗蠕虫药 三苯双脒 诱变性 致畸性 

分 类 号：R28[医药卫生—中药学]