立体定向放射治疗与脑血管介入栓塞疗法联合治疗高血运性脑肿瘤的效果及对神经功能的影响  

Efficacy of stereotactic radiotherapy combined with cerebral vascular interventional embolization for brain tumors complicated with high degree of vascularization and its influence on nerve function

作　　者：王祥业 崔长富 王妙茹 陆徽 WANG Xiang-ye;CUI Chang-fu;WANG Miao-ru;LU Hui(Department of Neurosurgery,Xi'an Arms Industry No.521 Hospital,Xi'an 710065,China;Department of Nursing Care,Affiliated Hospital of Xi'an Medical College,Xi'an 710309,China)

机构地区：[1]陕西省西安市兵器工业五二一医院神经外科,西安710065 [2]陕西省西安医学高等专科学校附属医院护理部,西安710309

出　　处：《中国肿瘤临床与康复》2020年第3期303-306,共4页Chinese Journal of Clinical Oncology and Rehabilitation

摘　　要：目的探讨立体定向放射治疗(SRT)与脑血管介入栓塞疗法联合治疗高血运性脑肿瘤的临床效果及对神经功能的影响。方法选取2016年4月至2018年4月间西安市兵器工业五二一医院收治的64例高血运性脑肿瘤患者,采用随机数表法分为研究组和对照组,每组32例。对照组患者采用SRT治疗,研究组患者在对照组基础上联合脑血管介入栓塞治疗,比较两组患者治疗总有效率、治疗前后神经功能变化、治疗期间不良反应及1年内生存率。结果研究组患者治疗总有效率为90.6%,高于对照组的59.4%,差异有统计学意义(P<0.05)。治疗后,研究组患者神经功能评分低于对照组,差异有统计学意义(P<0.05)。两组患者治疗期间均发生胃肠道反应、血液系统反应、黏膜反应与肝肾功能异常,但发生率比较,差异无统计学意义(P>0.05)。随访1年,研究组患者生存率为87.5%(28例),高于对照组的59.4%(19例),差异有统计学意义(P<0.05)。结论SRT与脑血管介入栓塞疗法联合治疗高血运性脑肿瘤疗效确切,可有效改善患者神经功能,延长生存时间,值得临床应用。Objective To investigate the effect of stereotactic radiotherapy(SRT)combined with cerebral vascular interventional embolization in the treatment of brain tumors complicated with high degree of vascularization and its influence on nerve function.Methods From April 2016 to April 2018,64 patients with brain tumors complicated with high degree of vascularization were selected at the Xi’an Arms Industry No.521 Hospital.They were divided into a study group and a control group with 32 patients in each group by random number table method.The study group was treated with cerebral vascular interventional embolization based on SRT and the control group was only treated with SRT.The overall efficacy rate,the changes in neurological function before and after treatment,the adverse reactions during treatment,and the survival rate within one year were compared between the two groups.Results The overall efficacy rate was 90.6%in the study group,which was higher than 59.4%of the control group(P<0.05).After treatment,National Institute of Health Stroke scale(NIHSS)score was lower in the study group than that in the control group(P<0.05).There was no significant difference in the incidence of gastrointestinal reaction,blood system reaction,mucous membrane reaction and liver and kidney dysfunction between the two groups(P>0.05).The 1-year survival rate was 87.5%(28 patients)in the study group which was higher than that59.4%(19 patients)of the control group(P<0.05).Conclusion SRT combined with cerebral vascular interventional embolization is effective in the treatment of brain tumors complicated with high degree of vascularization,and it can effectively improve the neurological function and prolong the survival period,which is worthy of clinical application.

关 键 词：立体定向放射治疗 脑血管介入栓塞疗法 高血运性脑肿瘤 神经功能 

分 类 号：R739.41[医药卫生—肿瘤]