钯催化糖苷化反应的研究进展  

Recent advances of Pd-catalyzed glycosylation

作　　者：仲烨 张作鹏[1] 程卯生[1] 刘洋[1] ZHONG Ye;ZHANG Zuo-peng;CHENG Mao-sheng;LIU Yang(Key Laboratory of Structure-Based Drugs Design&Discovery(Shenyang Pharmaceutical University),Ministry of Education,Shenyang 110016,China)

机构地区：[1]沈阳药科大学基于靶点的药物设计与研究教育部重点实验室,辽宁沈阳110016

出　　处：《中国药物化学杂志》2020年第10期613-621,共9页Chinese Journal of Medicinal Chemistry

基　　金：国家自然科学基金项目(81473087);辽宁省高等学校创新人才支持计划项目(LR2017043)

摘　　要：含有糖苷结构的天然产物具有多种理想的生物活性。随着糖化学的发展,糖苷的高效合成引起了越来越多的关注。金属Pd作为目前应用最广泛的过渡金属催化剂之一,因其反应条件温和、后处理操作简便等特点,已被广泛应用于一些高效的糖苷化反应策略中。本文综述了近年来报道的与Pd催化剂相关的O-糖苷化、N-糖苷化以及C-糖苷化策略,旨在为发展更加高效的糖苷化方法提供新的思路。The natural products with glycoside structure present many kinds of ideal biological activities.With the development of saccharide chemistry,the efficient synthesis of glycosides has drawn more and more attention.As one of the most widely used transition metal catalysts,palladium(Pd)catalyst has been widely used in high-efficiency glycosylation because of its mild reaction conditions and simple work-up operation.To provide new ideas for the development of more efficient glycosylation methods,the strategies of O-,N-and C-glycosylation related to Pd catalysts reported in recent years were reviewed in this paper.

关 键 词：PD催化剂 糖化学 糖苷化反应 研究进展 

分 类 号：R914[医药卫生—药物化学]