氟西汀联合奥氮平治疗对急性脑卒中后抑郁患者的临床效果  

Clinical effect of fluoxetine combined with olanzapine in patients with acute post-stroke depression

作　　者：王喜春[1] 马冲[1] 林霞 WANG Xichun;MA Chong;LIN Xia(Heilongjiang Provincial Hospital,Harbin 150036,China)

机构地区：[1]黑龙江省医院,黑龙江哈尔滨150036

出　　处：《心理月刊》2022年第15期74-76,共3页

摘　　要：目的分析急性脑卒中患者发生抑郁情绪后,采取抗抑郁治疗的效果。方法选择本院纳入的急性脑卒中抑郁患者作为观察对象,以随机数表法对患者分组,对照组患者采取氟西汀治疗,观察组采取氟西汀联合奥氮平治疗,观察两组患者治疗后的抑郁情况及神经功能缺损情况、生活质量、不良反应发生率。正态计量资料以t检验,计数资料以x^(2)检验。结果治疗前,两组患者抑郁评分对比无显著差异(P>0.05),治疗后,观察组患者抑郁评分显著低于对照组(P<0.05);观察组轻度神经功能缺损率高于对照组(P<0.05);观察组患者生活质量评分显著高于对照组(P<0.05);观察组患者不良反应发生率显著低于对照组(P<0.05)。结论在急性脑卒中合并抑郁患者治疗中,为患者采取联合用药治疗,安全性较高,患者抑郁情绪及生活质量显著改善,对改善患者神经功能缺损情况具有重要意义。Objective To analyze the effect of antidepressant treatment after depression in patients with acute stroke.Methods The patients with acute stroke depression included in our hospital were selected as the observation object,and the patients were divided into groups by random number method.The patients in the control group were treated with fluoxetine,and the patients in the observation group were treated with fluoxetine combined with olanzapine.The depression,neurological deficit,quality of life and incidence of adverse reactions were observed in the two groups after treatment.Normal measurement data were tested by t test,count data were tested by x^(2).Results Before treatment,there was no significant difference in depression scores between the two groups(P>0.05),and after treatment,the depression scores in the observation group were significantly lower than those in the control group(P<0.05);the mild neurological deficit rate in the observation group was higher than that in the control group(P<0.05);the quality of life score in the observation group was significantly higher than that in the control group(P<0.05);the incidence of adverse reactions in the observation group was significantly lower than that in the control group(P<0.05).Conclusion In the treatment of patients with acute stroke complicated with depression,taking combined medication for patients has high safety,significantly improved depression and quality of life,which is of great significance to improve the neurological deficit of patients.

关 键 词：抗抑郁治疗 急性脑卒中 抑郁 生活质量 神经功能缺损 

分 类 号：R743.3[医药卫生—神经病学与精神病学] R749.4[医药卫生—临床医学]