PNI应用于预测食管癌术后胸部并发症的意义  

Significance of application of PNI in predicting postoperative thoracic complications in esophageal cancer

作　　者：何垚 孙清超[2] 冉巍 邓彦超[2] HE Yao;SUN Qingchao;RAN Wei;DENG Yanchao(Xinjiang Medical University,Urumqi,830054,China;Department of Thoracic Surgery,the First Affiliated Hospital of Xinjiang Medical University,Urumqi 830054,China;Department of Plastic Surgery,the First Affiliated Hospital of Xinjiang Medical University,Urumqi,830054,China)

机构地区：[1]新疆医科大学,乌鲁木齐830054 [2]新疆医科大学第一附属医院胸外科,乌鲁木齐830054 [3]新疆医科大学第一附属医院烧伤整形科,乌鲁木齐830054

出　　处：《新疆医学》2022年第10期1131-1134,共4页Xinjiang Medical Journal

基　　金：2020年度省部共建中亚高发病成因与防治国家重点实验室食管癌研究专项立项项目(项目编号:SKL-HIDCA-2020-SG3)

摘　　要：目的探讨预后营养指数(Prognostic nutritional index,PNI)应用于预测食管癌术后胸部并发症的意义。方法根据纳入及排除标准,收集2018年6月-2021年5月因食管癌于新疆医科大学第一附属医院胸外科行食管癌根治术的患者的临床资料,根据PNI计算公式得出患者PNI,根据受试者工作特征曲线(receiver operating characteristic curve,ROC曲线)得出的最佳截点,将患者按最佳截点分为低PNI组和高PNI组,分析比较两组患者的临床资料及术后并发症发生情况。结果本研究纳入患者总数为214人,以48.49为截点将患者分为低PNI组93人和高PNI组121人,两组患者在总体并发症(P<0.001)、肺部炎症(P=0.014)、吻合口瘘(P=0.010)和肺不张(P=0.024)的发生率上的差异有统计学意义,低PIN组的总体并发症、肺部炎症、吻合口瘘和肺不张指标发生率高于高PNI组。结论PNI计算简便,容易获取,可应用于预测食管癌术后胸部并发症的发生,对术前评估提示中重度营养不良的患者给予营养干预可能会减少术后并发症的发生。Objective To study the significance of prognostic nutritional index(PNI)in predicting postoperative thoracic complications of esophageal cancer.Methods According to the inclusion and exclusion criteria,clinical data of patients who underwent radical esophageal cancer surgery for esophageal cancer in the department of thoracic surgery at the first affiliated hospital of Xinjiang Medical University from June 2018 to May 2021 were collected,PNI of patients was derived according to PNI calculation formula,and the patients were divided into low PNI group and high PNI group according to the optimal cut-off point derived from the receiver operating characteristic curve(ROC curve),and the clinical data and postoperative complications between the two groups were analyzed and compared.Results The total 214patients were included in this study.According to the cutoff point of 48.49,93 cases were divided into the low PNI group and 121 cases were in the high PNI group.The differences between the two groups were statistically significant in the incidence of overall complications(P<0.001),pulmonary inflammation(P=0.014),anastomotic fistula(P=0.010),and pulmonary atelectasis(P=0.024).The low-PIN group had the higher incidences of overall complications,pulmonary inflammation,anastomotic fistula and pulmonary dysplasia indicators than those in the high PNI group.Conclusion PNI is simple to calculate,easily accessible,and can be appliedto predict the occurrence of thoracic complications after esophagectomy.Nutritional intervention for patients with moderate or severe malnutrition suggested by preoperative evaluation may reduce the occurrence of postoperative complications.

关 键 词：食管癌 预后营养指数 术后胸部并发症 

分 类 号：R735.1[医药卫生—肿瘤]