多参数流式细胞术免疫表型分析在多发性骨髓瘤诊疗中的应用  

Multiparameter Immunophenotyping by Flow Cytometry in Diagnosis and Treatment of Multiple Myeloma

作　　者：林阳 万岁桂[2] LIN Yang;WAN Sui-gui(The Affiliated Yantai Yuhuangding Hospital of Qingdao University,Yantai 264000,China;Xuanwu Hospital,Capital Medical University,Beijing 100053,China)

机构地区：[1]青岛大学附属烟台毓璜顶医院,山东烟台264000 [2]首都医科大学宣武医院,北京100053

出　　处：《肿瘤学杂志》2020年第2期102-105,共4页Journal of Chinese Oncology

摘　　要：随着多发性骨髓治疗方法快速发展,对于该病的诊断、微小残留病灶监测及预后的判断有了越来越多的方式及方法,多参数流式细胞术免疫表型分析,通过细胞免疫表型的异质性及胞内轻链的克隆性,能够准确、客观的鉴别出良性及恶性浆细胞比例以及抗原表达水平,不仅为多发性骨髓瘤患者的诊断提供依据,同时能够追踪患者的微小残留病灶,这对预测多发性骨髓瘤患者的预后密切相关,全文将对多参数流式细胞术免疫表型分析在多发性骨髓瘤诊断、微小残留病灶监测及预后方面进行综述。The multiparameter immunophenotyping by flow cytometry can accurately and objectively identify the ratio of normal and malignant plasma cells and expression levels of multiple antigens through analysis of cellular immunophenotype heterogeneity and intracellular light chain clonality. It can not only provide the basis for the diagnosis,but also trace the minimal residual diseases of multiple myeloma,which are closely related to the prognosis of patients. This article reviews the application of multiparameter flow cytometryimmunophenotyping in the diagnosis,monitoring of minimal residual disease and prognosis of multiple myeloma patients.

关 键 词：流式细胞术 免疫表型 多发性骨髓瘤 诊断 微小残留病灶 

分 类 号：R733.3[医药卫生—肿瘤]