干细胞移植治疗炎症性肠病的研究进展  

Advances in Stem Cell Transplantation for the Treatment of Inflammatory Bowel Disease

作　　者：赵琳琳 梁锐 王志强 孙鹥[2] ZHAO Linlin;LIANG Rui;WANG Zhiqiang;SUN Yi(Medical Faculty,Kunming University of Science and Technology,Kunming 650500,China;Department of Clinical Laboratory,the First People’s Hospital of Yunnan Province,Kunming 650032,China;Department of Pathology,the Second Hospital of Tianjin Medical University,Tianjin 300211,China;Department of General Surgery,the Second Hospital of Tianjin Medical University,Tianjin 300211,China)

机构地区：[1]昆明理工大学医学院,昆明650500 [2]云南省第一人民医院检验科,昆明650032 [3]天津医科大学第二医院病理科,天津300211 [4]天津医科大学第二医院普外科,天津300211

出　　处：《中国细胞生物学学报》2019年第11期2220-2224,共5页Chinese Journal of Cell Biology

基　　金：国家自然科学基金(批准号:81660302);云南省应用基础研究计划(批准号:2013FZ179、2014FB040)资助的课题.

摘　　要：炎症性肠病包括克罗恩病和溃疡性结肠炎,其病程迁延、并发症严重,可引起严重的消化吸收障碍,甚至危及患者生命,是当今临床治疗上的一个重大医学难题。传统药物治疗方法不能有效治疗炎症性肠病,且会导致药物依赖及不良反应。研究发现,干细胞移植可修复肠道损伤,并恢复肠道的免疫系统,给炎症性肠病的治愈带来了新的希望。该文就造血干细胞、间充质干细胞、肠道干细胞、诱导性多能干细胞、孤雌胚胎干细胞等多种干细胞移植治疗炎症性肠病的研究进展作一综述。Inflammatory bowel disease,including Crohn’s disease and ulcerative colitis,has a prolonged course of disease,serious complications,can cause serious digestive dysfunction,and even endangers the life of patients.It is a major medical problem in clinical treatment today.Traditional medicines and treatments are not effective in treating inflammatory bowel disease and can lead to drug dependence and adverse reactions.The study found that stem cell transplantation can repair intestinal damage and restore the intestinal immune system,bringing new hope to the cure of inflammatory bowel disease.In this paper,the research progress of various stem cell transplantation such as hematopoietic stem cells,mesenchymal stem cells,intestinal stem cells,induced pluripotent stem cells and parthenogenetic embryonic stem cells for the treatment of inflammatory bowel disease is reviewed.

关 键 词：炎症性肠病 干细胞移植 治疗 

分 类 号：R574[医药卫生—消化系统]