幽门螺杆菌与慢性呼吸道疾病相关性的METa分析  

A METa-Analysis of the Relationship between Helicobacter Pylori and Chronic Respiratory Diseases

作　　者：岳倩宇[1] 李云涛 彭玉兰 王玉珏 邓小丽[1] YUE Qianyu;LI Yuntao;PENG Yulan;WANG Yujue;DENG Xiaoli

机构地区：[1]云南省第一人民医院(昆明理工大学附属昆华医院)呼吸与危重症专科,云南省昆明市650032

出　　处：《实用心脑肺血管病杂志》2021年第S01期14-16,共3页Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease

摘　　要：目的探讨幽门螺杆菌与慢性呼吸道疾病的相关性。方法用RevMan 5.2软件对符合纳入/排除标准的从Medline、Ovid、google学术、PubMed、Embase、中国知网、维普数据库、万方数据库中截止2016年11月30日有关幽门螺杆菌与慢性呼吸道疾病感染的文献进行质量评价和METa分析。依据纳入/排除标准筛选排除229项研究后共9项研究纳入METa分析(其中,CRDS病例734例,对照病例634例)。结果慢性呼吸道疾病发病组与对照组的幽门螺杆菌阳性比较时,I2=29%<50%,P=0.19>0.05,OR为3.81(95%CI:2.86,5.11),Z值为7.52(P<0.05)。进行亚组分析时,慢性阻塞性肺病组与对照组的幽门螺杆菌阳性比较时,I2=44%<50%,P=0.13>0.05,OR为3.45(95%CI:2.38,5.01),Z值为6.52(P<0.05),慢性支气管炎及哮喘组与对照组的幽门螺杆菌阳性比较时,OR为4.45(95%CI:2.81,7.06),I2=11%<50%,P=0.34>0.05,Z值为6.34(P<0.05)。结论幽门螺杆菌与慢性呼吸道疾病感染存在相关性,本文所得结果仅为阶段性研究成果,关于幽门螺杆菌与慢性呼吸道疾病感染相关性问题仍需基于多中心、多层样本数据的进一步研究。Objective To investigate the relationship between Helicobacter pylori and chronic respiratory diseases.Methods Conducted quality evaluation and METa analysis to literature on the infection of Helicobacter pylori and chronic respiratory tract infection in accordance with the inclusion and exclusion criteria as of November 30,2016 with RevMan 5.2 software,the literature was searched from Google,China academic CNKI,VIP database,PubMed,Embase,Medline,Ovid,Wanfang database.Results A total of 9 case-control studies comprising 734 cases and 634 controls were included in the study.When CRDS compared with the control group,I2=29%<50%,the OR was 3.81(95%CI:2.86,5.11),P=0.19<0.05,>,and Z value was 7.52(P<0.05).In subgroup analysis,when COPDcompared with the control group,I2=44%<50%,P=0.13<0.05,OR was 3.45(95%CI:2.38,5.01),and Z value was 6.52(P<0.05),when Chronic bronchitis and ASThma group compared with the control group,I2=11%<50%,P=0.34>0.05,OR was 4.45(95%CI:2.81,7.06),Z value was 6.34(P<0.05).Conclusion the result suggests a significant association between chronic respiratory tract infection and Helicobacter pylori infection.The results of this study are only stage research results,and the correlation between Helicobacter pylori infection and chronic respiratory disease is still need to be further verified by multi center and large sample.

关 键 词：慢性呼吸道疾病 幽门螺杆菌 CRDS META分析 

分 类 号：R573[医药卫生—消化系统] R56[医药卫生—内科学]