幼年性黄色肉芽肿二十例组织病理及皮肤镜特征分析  

Pathological and dermoscopy features analysis of juvenile xanthogranuloma in 20 cases

作　　者：党云[1] 向桂琼[1] 王丹丹[1] 樊卓[1] DANG Yun;XIANG Gui-qiong;WANG Dan-dan(Department of Dermatology,the First Affiliated Hospital of Xi'an Medical College,Xi’an 710077,China)

机构地区：[1]西安医学院第一附属医院,西安710077

出　　处：《实用皮肤病学杂志》2023年第4期202-205,共4页Journal of Practical Dermatology

基　　金：陕西省重点研发计划项目(2022SF-416)

摘　　要：目的探讨皮肤镜在幼年性黄色肉芽肿诊断中的应用价值。方法回顾性分析2018年7月—2021年3月西安医学院第一附属医院皮肤科确诊的20例幼年性黄色肉芽肿患者临床、组织病理资料及皮肤镜特征。结果幼年性黄色肉芽肿20例患者(男12例,女8例),平均发病年龄(2.12±4.29)岁。典型皮损表现为直径数毫米至数厘米的黄色、红色或棕色丘疹和结节,质硬,表面光滑。20例患者皮损均为单发。组织病理学表现为真皮内见边界相对清楚、无包膜的细胞团块,主要由组织细胞、Touton巨细胞及少量炎性细胞组成。20例幼年性黄色肉芽肿患者皮肤镜模式均表现为橘黄色、粉红色无结构区+血管结构,表现为落日征17例(85%)、苍白黄色球形云13例(65%)、白色条纹5例(25%)。血管结构呈不规则分布,其中线状血管60%、点状血管55%、分枝状血管35%。结论幼年性黄色肉芽肿患者皮肤镜下具有独特的表现,可作为其辅助诊断技术。Objective To explore the value of dermoscopy in the diagnosis of juvenile xanthogranuloma.Methods It was a retrospective study which analyzed the clinical,dermoscopic and pathological data of 20 cases with juvenile xanthogranuloma from July 2018 to March 2021 in our department.Results There were 12 males and 8 females.The average age at onset was 2.12±4.29 years old.Typical lesions are yellow,red or brown papules with a diameter of several millimetres to several centimetres in size,which have the hard and smooth surface.The skin lesions of 20 patients were single.Histopathologic examination showed well-circumscribed mass composed of foamy histiocytes inflammatory cells and Touton giant cells in the dermis.Among 20 patients the dermoscopic patterns of juvenile xanthogranuloma were yellow-orange and/or pink-red structureless color with vascular structures.The setting sun appearance were present in seventeen patients(85%),The clouds of paler yellow globules were present in thirteen patients(65%)whitish streak were present in five patients(25%).Vascular structures were observed in an irregular distribution,with linear vessels(60%),dotted vessels(55%),and branched vessels(35%).Conclusion Juvenile xanthogranuloma has characteristic dermatoscopic patterns which can be used as an auxiliary diagnostic technique of juvenile xanthogranuloma.

关 键 词：黄色肉芽肿 幼年性 临床表现 组织病理 皮肤镜 

分 类 号：R739.5[医药卫生—肿瘤]