甘草次酸的结构修饰及生物活性研究进展  

Research Progress in Structure Modification and Biological Activity of Glycyrrhetinic Acid

作　　者：张光辉[1] 龙旭[1] 张拴[1] 郭惠[1] 孟庆华[1] 韦陈彬 任兴鹏 ZHANG Guang-hui;LONG Xu;ZHANG Shuan;GUO Hui;MENG Qing-hua;WEI Chen-bin;REN Xing-peng(Shaanxi University of Chinese Medicine,Shaanxi Xianyang 712046,China)

机构地区：[1]陕西中医药大学,陕西咸阳712046

出　　处：《当代化工》2020年第2期393-397,共5页Contemporary Chemical Industry

基　　金：陕西省科技厅项目,项目号:2016SF-102;陕西省高校科协青年人才托举计划项目,项目编号:20170406.

摘　　要：甘草次酸是甘草中重要的黄酮之一,其具有明显的抗炎、抗溃疡、抗肿瘤、抗病毒、抗氧化、美白等活性,在食品、药品等行业得到广泛应用,并越来越受到科研人员的关注。目前,甘草次酸结构修饰主要集中在C-3、C-30、C-11位。就甘草次酸结构修饰及甘草次酸衍生物的生物活性进行了探讨,为甘草次酸衍生物的合成及甘草次酸的开发提供参考依据。Glycyrrhetinic acid is one of the important flavonoids in licorice,which has obvious anti-inflammatory,anti-ulcer,anti-tumor,anti-virus,anti-oxidation,whitening and other activities.At present,the structural modification of glycyrrhetinic acid mainly focuses on c-3,c-30 and c-11 positions.In this paper,structural modification of glycyrrhetinic acid and biological activity of its derivatives were discussed,providing reference for the synthesis of the derivatives and the development of glycyrrhetinic acid.

关 键 词：甘草次酸 结构修饰 活性 

分 类 号：R284[医药卫生—中药学]