Cytokine Profiles and Virological Marker Monitoring during 48 Weeks Peginterferon Alfa Treatment for HBeAg-Positive Chronic Hepatitis B  

作　　者：LI Ming Hui SUN Fang Fang CHEN Feng Xin ZENG Zhan LIN Yan Jie BI Xiao Yue YANG Liu DENG Wen JIANG Ting Ting HUANG Rong Hai YI Wei XIE Yao 

机构地区：[1]Department of Hepatology Division 2,Beijing Ditan Hospital,Capital Medical University,Beijing 100015,China [2]Department of Hepatology Division 2,Peking University Ditan Teaching Hospital,Beijing 100015,China [3]Capital Medical University,Beijing 100069,China [4]Department of Infectious Diseases,Capital Medical University,Beijing 100015,China [5]Department of General Surgery,Capital Medical University,Beijing 100015,China [6]Department of Gynecology and Obstetrics,Beijing Ditan Hospital,Capital Medical University,Beijing 100015,China

出　　处：《Biomedical and Environmental Sciences》2022年第4期312-321,共10页生物医学与环境科学（英文版）

基　　金：funded in part by Beijing Hospitals Authority Clinical Medicine Development of Special Funding support[XMLX 201706 and XMLX 202127];the Digestive Medical Coordinated Development Center of Beijing Hospitals Authority[XXZ0302 and XXT28];the National Science and Technology Major Project of China[2017ZX10201201-001-006,2017ZX10201201-002-006,and 2018ZX10715-005-003-005];the Beijing Municipal Science&Technology Commission[Z151100004015122];the Beijing Science and Technology Commission[D161100002716002];the Special Public Health Project for Health Development in Capital[2021-1G-4061]

摘　　要：Objective This study aimed to investigate whether cytokine profiles and virological markers might add value in monitoring the effects of peginterferon(PEG-IFN)therapy for hepatitis B e-antigen(HBeAg)positive chronic hepatitis B(CHB).Methods HBeAg positive patients with CHB were treated with PEG-IFN for 48 weeks.Clinical biochemical,and HBV serological indexes,as well as cytokines,were detected at baseline and every12 weeks.Results A total of 116 patients with CHB were enrolled in this study;100 patients completed the 48-week treatment and follow-up,of whom 38 achieved serum HBeAg disappearance,25 achieved HBeAg seroconversion,37 showed HBsAg decreases≥1 log10 IU/mL,9 showed HBsAg disappearance,and 8became HBsAb positive.The cytokine levels at baseline and during treatment were similar between the HBeAg disappearance group and non-disappearance group.The disappearance of HBeAg was independently associated with HBeAg levels at weeks 12 and 24,and with the HBeAg decline at week 24(P<0.05).The HBsAg response was independently associated with HBsAg,the HBsAg decline,HBeAg,the HBeAg decline at week 12,and HBsAg at week 24(P<0.05).Conclusion There was no significant correlation between the response to interferon(IFN)and cytokines during PEG-IFN treatment.The changes in virological markers predicted the response to IFN after 48 weeks.

关 键 词：Chronic hepatitis B CYTOKINE PEGINTERFERON HBSAG HBEAG 

分 类 号：R512.62[医药卫生—内科学]