STC1在生殖相关肿瘤中的作用与分子机制  

Role and molecular mechanism of STC1 in reproduction-related tumors

作　　者：刘丽 胡军[1,3] 张静[1,2,3] 黄萃园 王伟 涂晓坤 杨超君 张吉英[1,3] 曾萍 LIU Li;HU Jun;ZHANG Jing;HUANG Cuiyuan;WANG Wei;TU Xiaokun;YANG Chaojun;ZHANG Jiying;ZENG Ping(The First College of Clinical Medical Science,China Three Gorges University,Yichang 443003,China;Hubei Clinical Research Center for Ischemic Cardiovascular Disease,Yichang 443003,China;Central Laboratory,Yichang Central People’s Hospital,Yichang 443003,China)

机构地区：[1]三峡大学第一临床医学院,宜昌443003 [2]湖北省缺血性心血管疾病临床研究中心,宜昌443003 [3]宜昌市中心人民医院中心实验室,宜昌443003

出　　处：《生命的化学》2023年第1期63-68,共6页Chemistry of Life

基　　金：国家自然科学基金项目(82170418);湖北省教育厅科研中青年项目(Q20221211);宜昌市医疗卫生研究项目(A21-2-011)

摘　　要：斯钙蛋白1(stanniocalcin 1,STC1)是一种调节血浆钙磷平衡的糖蛋白激素。之前STC1的研究多集中于钙磷平衡、氧化应激、炎症反应等过程。近来研究发现,STC1在肿瘤的发生、生长、增殖、凋亡、侵袭转移等过程中发挥了重要作用。本文对STC1在生殖相关肿瘤,如乳腺癌、卵巢癌、宫颈癌、前列腺癌和膀胱癌中的研究进展进行综述,总结了STC1在不同肿瘤中的表达、作用机制以及与肿瘤预后的关系,旨在为肿瘤治疗提供新思路。Stanniocalcin 1(STC1)is a glycoprotein hormone that regulates plasma calcium and phosphorus balance.Previous studies on STC1 mostly focused on calcium and phosphorus balance,oxidative stress,inflammatory response,etc.Recent studies have found that STC1 plays an important role in tumorigenesis,growth,proliferation,apoptosis,invasion and metastasis of tumors.This paper reviews the expression of STC1,its mechanism and its relationship with tumor prognosis in the reproductive-related tumors,such as breast cancer,ovarian cancer,cervical cancer,prostate cancer and bladder cancer,to provide new ideas for tumor treatment.

关 键 词：斯钙蛋白1 生殖相关肿瘤 肿瘤发生发展 不良预后 

分 类 号：R737[医药卫生—肿瘤]