AP-1在恶性肿瘤领域的作用  

Roles of AP-1 in malignant tumor

作　　者：夏俊凯 宋捷 文雪梅 梁文波 XIA Junkai;SONG Jie;WEN Xuemei;LIANG Wenbo(Xinhua Clinical College of Dalian University,Dalian 116000,China;Department of Medicine,Dalian University,Dalian 116000,China)

机构地区：[1]大连大学附属新华医院,大连116000 [2]大连大学医学部,大连116000

出　　处：《生命的化学》2022年第12期2141-2147,共7页Chemistry of Life

基　　金：大连市高层次人才创新支持计划项目(2021RQ030)

摘　　要：转录因子激活蛋白-1(activator protein-1,AP-1)在某些特定因素的作用下会被过度激活,导致其异常表达,从而在多种疾病的发生与发展中发挥作用。尤其是在恶性肿瘤的发生发展中,AP-1的过表达可以促进肿瘤发生发展、增殖分化、浸润转移并影响其耐药。抑制AP-1的活性能够延缓肿瘤的进程,故AP-1或可成为肿瘤治疗的新靶点。本文介绍了AP-1的结构与功能,回顾了近年来AP-1在肿瘤生长调控中的作用机制以及其靶向药物制剂开发的相关研究,旨在对当前相关研究进行总结归纳,以期阐明现阶段AP-1在恶性肿瘤治疗中的作用机制,为恶性肿瘤的靶向治疗提供参考。Transcription factor activating protein-1(AP-1)is over-activated by certain factors,leading to its abnormal expression,which plays a role in the occurrence and development of various diseases.Especially in the occurrence and development of malignant tumors,the overexpression of AP-1 can promote tumor occurrence and development,proliferation and differentiation,invasion and metastasis,and affect drug resistance.Studies have shown that the process of tumor can be delayed by inhibiting the activity of AP-1.Therefore,AP-1 may become a new target for tumor therapy.This article introduces the structure and function of AP-1,reviews the mechanism of action of AP-1 in the regulation of tumor growth and the relevant studies on the development of its targeted drugs in recent years,and aims to summarize the current relevant studies,in order to clarify the mechanism of action of AP-1 in the treatment of malignant tumors and provide reference for the targeted therapy of malignant tumors.

关 键 词：激活蛋白-1 恶性肿瘤 Jun蛋白 FOS蛋白 转录因子 

分 类 号：R730.2[医药卫生—肿瘤]