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作 者:郭欣煜 王菲叶 许云[1] 龚璐天 付力 曾钰梅 杨宇飞[1] GUO Xinyu;WANG Feiye;XU Yun;GONG Lutian;FU Li;ZENG Yumei;YANG Yufei(Xiyuan Hospital of China Academy of Chinese Medical Sciences,Beijing 100091,China;Xiyuan Clinical Medical College of Beijing University of Traditional Chinese Medicine,Beijing 100029,China)
机构地区:[1]中国中医科学院西苑医院,北京100091 [2]北京中医药大学西苑临床医学院,北京100029
出 处:《世界科学技术-中医药现代化》2024年第5期1290-1297,共8页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology
基 金:国家自然科学基金委员会面上项目(82074414):基于ASCT2/GS介导的谷氨酰胺代谢途径探讨祛邪胶囊干预结肠癌机制研究,负责人:许云;中国中医科学院科技创新工程重大攻关项目(CI2021A01807):基于肠道微生态的结直肠癌的寒热证候特征与优势人群干预方案精准化研究,负责人:许云
摘 要:实验动物模型是结直肠癌基础研究中必不可少的环节。构建以中医辨证论治理论为基础的中医特色的病证结合动物模型,使动物模型既符合西医疾病特征又具备中医证候的特点,对中医药治疗结直肠肿瘤的基础研究有重要意义。本文通过文献梳理的方式总结了当前常用的结直肠肿瘤动物模型和病证结合动物模型的构建方法与特点,以期为从事结直肠肿瘤科学研究的科研工作者提供参考。Experimental animal models are an essential part of basic research on colorectal cancer.It is important for basic research on colorectal tumor treatment in TCM to construct animal models with the characteristics of TCM based on the theory of TCM diagnosis and treatment,so that the animal models can meet the characteristics of both western medicine and TCM symptoms.In this paper,we summarize the methods and characteristics of animal models of colorectal tumors and the combination of disease and evidence for scientific research on colorectal tumors through literature review,in order to provide reference for researchers engaged in scientific research on colorectal tumors.
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