铁死亡与溃疡性结肠炎及中医药治疗研究进展  

Research Progress on Ferroptosis,Ulcerative Colitis and Treatment with Traditional Chinese Medicine

作　　者：李晓彤 李家立[1] 曹志群 康楠[1] 孔维枝[2] 由智栋 LI Xiaotong;LI Jiali;CAO Zhiqun;KANG Nan;KONG Weizhi;YOU Zhidong(Affiliated Hospital of Jining Medical College,Jining 272029,China;The First Clinical Medical College of Shandong University of Traditional Chinese Medicine,Jinan 250355,China;Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Jinan 250012,China;College of Nursing,Jining Medical College,Jining 272067,China)

机构地区：[1]济宁医学院附属医院,济宁272029 [2]山东中医药大学第一临床医学院,济南250355 [3]山东中医药大学附属医院,济南250012 [4]济宁医学院护理学院,济宁272067

出　　处：《世界科学技术-中医药现代化》2024年第4期861-867,共7页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：国家自然科学基金委员会青年基金(81804064):基于SGLT1/p38MAPK/NHE3通路探讨参苓白术散治疗功能性腹泻脾虚证机制研究,负责人:康楠;山东省中医药管理局重点项目(2021Z039):基于肠道菌群-短链脂肪酸-肠黏膜屏障探讨参苓白术药膳糊防治脾虚泄泻的作用机制研究,负责人:康楠;济宁市科技局重点计划(2022YXNS166):基于SGK1-Nedd4-2-ENaC通路探讨参苓白术药膳糊治疗脾虚泄泻的疗效及机制研究,负责人:康楠

摘　　要：溃疡性结肠炎是一种慢性非特异性炎症性疾病,其肠道上皮细胞的持续性损伤是疾病发生发展的关键。近年来,研究人员发现了一种新形式的细胞死亡方式——铁死亡,这被认为是导致肠道上皮细胞死亡的重要因素。铁死亡的发生往往与细胞内铁代谢异常、胱氨酸/谷氨酸反向转运体活性降低、脂质代谢异常、电压依赖性阴离子通道激活以及Nrf2基因过度表达等因素相关。铁死亡能够导致线粒体变小、膜密度增加和嵴数量减少,与传统的细胞死亡方式不同,其并不表现出特定的现象。相关研究发现,中医药能够通过降低细胞内铁含量、抑制脂质活性氧产生、调节Nrf2基因表达等途径来缓解肠上皮细胞的铁死亡,从而起到治疗溃疡性结肠炎的作用。因此,中医药可能成为治疗溃疡性结肠炎的一种重要手段。本文就细胞铁死亡与溃疡性结肠炎的关系以及中医药通过铁死亡通路治疗溃疡性结肠炎的研究进展进行综述。Ulcerative colitis is a chronic,non-specific inflammatory disease.The persistent damage to its intestinal epithelium is key to the development of the disease.In recent years,a new form of cell death has been identified by researchers-iron death-which is thought to be an important contributor to intestinal epithelial cell death.The occurrence of iron death is often associated with abnormal intracellular iron metabolism,reduced cystine/glutamate reverse transporter activity,abnormal lipid metabolism,voltage-dependent anion channel activation and overexpression of the Nrf2 gene.Iron death can lead to smaller mitochondria,increased membrane density and reduced number of cristae,unlike conventional cell death,which does not exhibit specific phenomena.Studies have found that TCM can alleviate iron death in intestinal epithelial cells by reducing intracellular iron content,inhibiting lipid reactive oxygen species production and regulating Nrf2 gene expression,thus acting as a treatment for ulcerative colitis.Therefore,Chinese medicine may become an important tool for the treatment of ulcerative colitis.This paper reviews the relationship between cellular iron death and ulcerative colitis and the research progress of Chinese medicine in treating ulcerative colitis through the iron death pathway.

关 键 词：铁死亡 溃疡性结肠炎 炎症性肠病 中医药治疗 

分 类 号：R574.62[医药卫生—消化系统]