基于细胞自噬探讨中医药防治肝纤维化的作用机制研究  

Study on the Mechanism of TCM Prevention and Treatment of Liver Fibrosis Based on Autophagy

作　　者：田晓玲 唐陈琴 张彧 陈斌[2] Tian Xiaoling;Tang Chenqin;Zhang Yu;Chen Bin(First Clinical College of Traditional Chinese Medicine,Hunan University of Traditional Chinese Medicine,Changsha 410208,China;The First Affiliated Hospital of Hunan University of Chinese Medicine,Changsha 410007,China)

机构地区：[1]湖南中医药大学第一中医临床学院,长沙410208 [2]湖南中医药大学第一附属医院,长沙410007

出　　处：《世界科学技术-中医药现代化》2023年第11期3692-3703,共12页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：湖南省卫生健康委员会重点科研课题(202103081452):基于网络药理学预测的PI3K-Akt信号通路研究赤芍-附片治疗肝衰竭的协同作用机制,负责人:陈斌;国家自然科学基金委员会面上项目(81673959):基于Treg/Th17细胞失衡研究清温并用法调控肝衰竭炎症反应的作用机制,负责人:陈斌

摘　　要：肝纤维化(Hepatic fibrosis,HF)是多种慢性肝病共有的病理过程,也是肝硬化的早期可逆阶段,阻止或逆转肝纤维化是减少肝硬化、肝癌发生的关键。肝纤维化的发展是一个复杂而动态的过程,涉及多种细胞和分子机制。细胞自噬功能障碍可能是导致HF疾病进展的重要因素。近年来,研究人员开始着力于寻找能够通过调节细胞自噬来逆转HF的药物。随着研究的深入,中医药在肝纤维化防治中不断有新突破,越来越多的研究证实了中医药可通过干预自噬来发挥治疗HF的作用,其作用效果可概括为促进细胞自噬(补其不足)和抑制细胞自噬(损其有余)两个方面,最终使自噬微环境恢复平衡,从而起到抗纤维化作用。Hepatic fibrosis(HF)is a common pathological process of many chronic liver diseases,and it is also the early reversible stage of cirrhosis.To prevent or reverse hepatic fibrosis is the key to reduce the occurrence of liver cirrhosis and liver cancer.The development of hepatic fibrosis is a complex and dynamic process involving multiple cellulars and molecular mechanisms.More and more studies have shown that dysfunction of autophagy may be an important factor leading to the progression of HF.In recent years,researchers have begun to look for drugs that can reverse HF by regulating autophagy.With the depth of study,TCM continues to make new breakthroughs in the prevention and treatment of liver fibrosis.More and more studies have confirmed that TCM can play a role in the treatment of HF by intervening in autophagy,and its effects can be summarized into two aspects:promoting autophagy(filling its deficiency)and inhibiting autophagy(damaging its excess),and finally restoring the balance of autophagy microenvironment.Thus,it has an anti-fibrosis effect.

关 键 词：细胞自噬 肝纤维化 中医药 作用机制 

分 类 号：R575.2[医药卫生—消化系统]