高血压动物模型的造模方法与评价  

Modeling Method and Evaluation of Animal models of Hypertensive

作　　者：都梦岩 吴威 李威莹 姜晓西 孟岩 杨关林[3] 张会永[4] Du Mengyan;Wu Wei;Li Weiying;Jiang Xiaoxi;Meng Yan;Yang Guanlin;Zhang Huiyong(Graduate School of Liaoning University of Traditional Chinese Medicine,Shenyang 110847,China;Zhuhai College of Science and Technology,Zhuhai 519041,China;Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang 110032,China;Key Laboratory of Ministry of Education for TCM Viscera State Theory and Applications,Liaoning University of Traditional Chinese Medicine,Shenyang 110847,China)

机构地区：[1]辽宁中医药大学研究生学院,沈阳110847 [2]珠海科技学院,珠海519041 [3]辽宁中医药大学附属医院,沈阳110032 [4]辽宁中医药大学中医脏象理论及应用国家教育部重点实验室,沈阳110847

出　　处：《世界科学技术-中医药现代化》2023年第10期3254-3263,共10页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：国家自然科学基金委员会青年科学基金项目(81603513):基于“脾病,脉道不利”探讨脾虚痰浊小猪dyHDL对冠脉内皮S1PR1/PI3K/Akt的分子调控机制,负责人:张会永;广东省自然科学基金委员会面上项目(2021A1515011485):基于AR靶点的大独活香豆素类抗前列腺癌药效物质基础及其分子作用机制研究,负责人:吴威;国家中医药管理局国家中医药领军人才支持计划(国中医药人教发[2018]12号):国家中医药管理局中医药传承与创新“百千万”人才工程(岐黄工程)岐黄学者,负责人:张会永

摘　　要：高血压是导致心血管病死亡的主要因素之一。2021年我国心血管病患病人数约3.3亿,其中高血压达2.45亿人,但1991-2018年高血压治疗率和控制率皆低于45.8%,故开展高血压相关研究具有重要的临床意义和社会价值。高血压动物模型是探究高血压发病机制和评价降血压药物研发的重要工具。目前高血压动物模型造模方法较多,笔者通过查阅和整理国内外高血压动物模型相关文献,从遗传、手术诱导、环境诱导、药物诱导4个方面,对高血压常用动物模型的造模方法、原理、特点及应用进行总结探讨,以期为选择和建立更科学的高血压动物模型提供参考,为中西医治疗高血压及其并发症的研究奠定基础。Hypertension is one of the main factors leading to cardiovascular death.The number of cardiovascular patients were about 330 million in China,and 245 million among them were suffering from hypertensive in 2021.The rates of treatment and control of hypertension were less than 45.8%from 1991 to 2018.Therefore,it is of great clinical significance and social value to carry out hypertension related research.Animal models of hypertension are important tools to explore the pathogenesis of hypertension and evaluate the development of antihypertensive agents.At present,there are many ways to establish animal models of hypertension,by consulting and sorting out the relevant papers of animal models of hypertension at home and abroad,the author summarized and discussed the replication methods,principles,features and applications of commonly used animal models from four aspects,such as genetics,surgical induction,environmental induction and pharmaceuticals induction,in order to provide a reference for the selection and establishment of more scientific animal models of hypertension and lay the foundation for the combined treatment of hypertension with Chinese and Western medicine.

关 键 词：高血压 动物模型 造模方法 模型评价 应用 

分 类 号：R-332[医药卫生]