基于因子分析的558例肾阳虚证人群的证候量化分析研究  

Quantitative Analysis of Syndromes in 558 Cases of Kidney Yang Deficiency Syndrome Based on Factor Analysis

作　　者：王舒月 赵宗江[1] 张新雪[1] 严祖桢 张燕 张志梅 焦婷婷 吴琪 刘运华[1] 王思童 张新江 周楷栋 Wang Shuyue;Zhao Zongjiang;Zhang Xinxue;Yan Zuzhen;Zhang Yan;Zhang Zhimei;Jiao Tingting;Wu Qi;Liu Yunhua;Wang Sitong;Zhang Xinjiang;Zhou Kaidong(Beijing University of Chinese Medicine,Beijing 102488,China;Wangsiying Community Health Service Center,Beijing 100124,China)

机构地区：[1]北京中医药大学,北京102488 [2]王四营社区卫生服务中心,北京100124

出　　处：《世界科学技术-中医药现代化》2023年第7期2304-2312,共9页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：国家科学技术部国家重点研发计划资助项目(2018YFC1704300):“肾阳虚证”辨证标准的系统研究,负责人:王拥军;国家科学技术部国家重点研发计划资助项目子课题(2018YFC1704304):慢性肾脏病“肾阳虚证”辨证标准的系统研究,负责人:赵宗江。

摘　　要：目的通过对558例肾阳虚证人群量化的证候信息进行因子分析以揭示肾阳虚证的构成规律,为肾阳虚证证候的客观化、标准化和规范化研究提供临床数据支持。方法首先对558例肾阳虚证人群的症状和舌脉体征进行频数统计分析,然后将肾阳虚证人群的主要证候信息量化,最后通过因子分析筛选出肾阳虚证的公因子及其代表性变量,并结合中医证候知识分析肾阳虚证的构成规律。结果应用主成分分析法提取了特征值大于1的8个公因子,累计贡献率为60.483%,经因子旋转后筛选出各公因子中载荷系数绝对值大于0.45的代表性变量,其中F1的代表性变量为畏寒喜暖(0.947)、不耐寒冷(0.932),F2的代表性变量为腰部酸痛(0.754)、腰膝酸软(0.720)、腰膝怕冷(0.466),F3的代表性变量为情绪低落(0.749)、不寐(0.711)、五更泄泻(0.470),F4的代表性变量为苔薄(0.819)、苔白(0.768),F5的代表性变量为耳鸣耳聋(0.687)、夜尿频多(0.591)、性欲减退(0.587),F6的代表性变量为脉沉(0.766)、脉弱(0.736),F7的代表性变量为脉细(0.942),F8的代表性变量为舌淡(0.961),这些公因子涉及的病位外候为腰、骨、脑、耳、前后二阴及生殖功能,病性为虚和寒。结论肾阳虚证的基本构成单位包括病位证候要素和病性证候要素,其病位在肾,肾之病位异常变化以腰、骨、脑、耳、前后二阴及生殖功能为主要外候;其病性为虚寒,所谓“阳虚则外寒”,由于阳气虚衰不能温煦体表,导致了外寒证候的出现。Objective Through factor analysis of the quantified syndrome information of 558 cases of kidney yang deficiency syndrome,the constructing feature of kidney yang deficiency syndrome was revealed,which provides clinical data support for the objectification,standardization and normalization of kidney Yang deficiency syndrome.Methods Firstly,the frequency analysis of symptoms,tongue and pulse signs of 558 patients with kidney Yang deficiency syndrome was carried out,and then the main syndrome information of the patients with kidney Yang deficiency syndrome was quantified.Finally,the common factors and their representative variables of kidney Yang deficiency syndrome were screened out through factor analysis,and the constructing feature of kidney Yang deficiency syndrome was analyzed combined with TCM syndrome knowledge.Results Eight common factors with eigenvalues greater than 1 were extracted by principal component analysis,and the cumulative contribution rate was 60.483%.After the factor rotation,the representative variables with the absolute value of load coefficient greater than 0.45 in each common factor were selected.The representative variables of F1 are afraid of cold and fond of warmth(0.947)and intolerance to cold(0.932).The representative variables of F2 are waist pain(0.754),waist and knee weakness(0.720)and cold in waist and knees(0.466).The representative variables of F3 are depression(0.749),insomnia(0.711)and diarrhoea(0.470).The representative variables of F4 are thin fur(0.819)and white fur(0.768).The representative variable of F5 are tinnitus and deafness(0.687),frequent nocturnal urination(0.591)and decreased libido(0.587).The representative variables of F6 are pulse sinking(0.766)and pulse weakness(0.736).The representative variables of F7 is thready pulse(0.942).The representative variable of F8 is pale tongue(0.961).External syndrome of disease location involved in these common factors are waist,bone,brain,ear,anterior Yin,posterior Yin and reproductive function.The disease nature involved in t

关 键 词：肾阳虚证 证候量化 因子分析 公因子 

分 类 号：R-058[医药卫生]