基于复杂网络分析肺癌术后优势人群有效核心处方的发现及实验验证  

Discovery and Experimental Verification of Effective Core Prescriptions Based on complex Network Analysis for the Advantaged Population after Lung Cancer Surgery

作　　者：方旭鹏 徐振晔[1] 王中奇[1] 邓海滨[1] 苏婉[1] 蔡玥娇[1] 谢振颖[1] 王立芳[1] Fang Xupeng;Xu Zhenye;Wang Zhongqi;Deng Haibin;Su Wan;Cai Yuejiao;Xie Zhenying;Wang Lifang(Long Hua Hospital Shanghai University of Traditional Chinese Medicine,Shanghai 20032,China)

机构地区：[1]上海中医药大学附属龙华医院,上海200032

出　　处：《世界科学技术-中医药现代化》2023年第4期1224-1229,共6页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：上海市卫生健康委员会、上海市中医药管理局中医药事业传承与发展(Z155080000004):基于中医临床基地优势病种的中医临床疗效评价能力提升项目,负责人:王中奇;上海市教育委员会重大项目(2017-01-07-00-10-E00064):源于精气理论的肺岩宁方抗肺癌生长与转移作用机制的研究,负责人:邓海滨;国家中医药管理局:徐振晔全国名老中医药专家传承工作室,负责人:徐振晔

摘　　要：目的运用复杂网络分析挖掘中医药防治肺癌术后复发转移优势人群的核心处方,对核心处方进行有效性评价。方法收集829例肺癌术后无进展生存期大于2年的患者,运用复杂网络分析的方法挖掘核心中药处方,通过建立C57BL/6小鼠Lewis肺癌术后动物模型,进行核心处方的有效性评价。结果优势人群中出现复发转移和未出现复发转移两组人群各挖掘出处方5张,动物实验表明中药可以有效防治肺癌术后复发转移,延长小鼠生存时间,提高小鼠体质量(P<0.05),同时以未复发转移人群核心处方干预,肺癌术后小鼠复发肺部转移瘤发生更少,生存时间更长。结论运用复杂网络分析可以对肺癌术后临床资料进行处方挖掘,挖掘所得的核心处方初步验证有良好的效果。Objective Use complex network analysis to mine the core prescriptions of traditional Chinese medicine for the prevention and treatment of postoperative recurrence and metastasis of lung cancer,and evaluate the effectiveness of the core prescriptions.Methods A total of 829 patients with postoperative progression-free survival of lung cancer greater than 2 years were collected,the core traditional Chinese medicine prescriptions were mined by complex network analysis,and the effectiveness of the core prescriptions was evaluated by establishing the C57BL/6 mouse Lewis lung cancer postoperative animal model.Results Advantage the crowd has spread to the recurrence,metastasis and recurrence of does not appear two groups excavated prescription 5 pieces,each animal experiments show that Chinese medicine can be effective prevention and treatment of postoperative recurrence of lung cancer metastasis,prolong the survival time of mice,increase the weight of mice(P<0.05),and at the same time to transfer not recurrence core prescription intervention,lung cancer,less postoperative recurrence of lung metastases occur in mice,Survival time is longer.Conclusion Complex network analysis can be used to mine the clinical data after lung cancer surgery,and the core prescriptions obtained from mining have a good effect.

关 键 词：数据挖掘 遗传算法 核心处方 中医药 肺癌术后 复发转移 

分 类 号：R-058[医药卫生]