术中穴位埋线对肺癌胸腔镜手术患者免疫状态的影响  

Effects of intraoperative catgut implantation at acupoint on immune status of lung cancer patients undergoing thoracoscopic surgery

作　　者：张娇娇 陈彤宇[2] 葛文[2] 徐建俊[2] 吴瑶瑶[2] 池浩[2] ZHANG Jiaojiao;CHEN Tongyu;GE Wen;XU Jianjun;WU Yaoyao;CHI Hao(Shuguang Clinical Medical College,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China;Department of Cardiothoracic Surgery,Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China)

机构地区：[1]上海中医药大学曙光临床医学院,上海201203 [2]上海中医药大学附属曙光医院心胸外科,上海201203

出　　处：《上海中医药杂志》2020年第S01期29-31,46,共4页Shanghai Journal of Traditional Chinese Medicine

基　　金：上海市科委科研计划项目(16401931100).

摘　　要：目的观察术中穴位埋线疗法对肺癌胸腔镜手术患者免疫状态的影响。方法将100例肺癌胸腔镜手术患者随机分为埋线组49例和对照组51例。所有患者均予常规术后处理,埋线组患者术后予穴位埋线。于术前1 d、手术当日及术后1 d、2 d、3 d采集血样,检测患者的肿瘤坏死因子(TNF)、干扰素(IFN-γ)、白细胞介素(IL-1、IL-2、IL-6、IL-8、IL-10)、血管内皮生长因子(VEGF)、免疫细胞(CD2^+、CD3^+、CD4^+、CD8^+、CD28^+)、自然杀伤细胞(NK细胞)、免疫球蛋白(IgG、IgA、IgM)水平。结果各时间点两组患者的CD3^+、CD28^+、NK细胞及IgM水平比较,差异均有统计学意义(P<0.05,P<0.01);手术当日及术后1 d、2 d,两组患者的IL-8、IL-10水平比较,差异有统计学意义(P<0.05,P<0.01);手术当日及术后1 d、3 d,两组患者的CD2^+、CD8^+水平比较,差异有统计学意义(P<0.05,P<0.01);手术当日及术后1 d,两组患者的CD4^+水平比较,差异有统计学意义(P<0.01)。结论术中穴位埋线对肺癌胸腔镜手术患者的免疫相关指标具有一定的调节作用。Objective To observe the effects of intraoperative catgut implantation at acupoint on immune status of lung cancer patients undergoing thoracoscopic surgery. Methods A total of 100 lung cancer patients undergoing thoracoscopic surgery were randomly divided into the catgut embedding group(49 cases)and the control group(51 cases).All patients were treated with routine postoperative treatment,and the catgut embedding group was treated with catgut implantation at acupoint after surgery.One day before operation,on the same day of operation and one,two and three days after operation,the blood sample was collected.The levels of tumor necrosis factor(TNF),interferon(IFN-γ),interleukin(IL-1,IL-2,IL-6,IL-8,IL-10),vascular endothelial growth factor(VEGF),immune cells(CD2^+,CD3^+,CD4^+,CD8^+,CD28^+),natural killer cells(NK cells)and immunoglobulin(IgG,IgA,IgM)were measured. Results There were statistically significant differences in the levels of CD3^+,CD28^+,NK cells and IgM between the two groups at each time point(P<0.05,P<0.01).On the same day of operation and one and two days after operation,there were statistically significant differences in the levels of IL-8 and IL-10 between the two groups(P<0.05,P<0.01).On the same day of operation and one and three days after operation,there were statistically significant differences in the levels of CD2^+ and CD8^+ between the two groups(P<0.05,P<0.01).On the same day of operation and one day after operation,there was statistically significant difference in the level of CD4^+ between the two groups(P<0.01). Conclusion Intraoperative catgut implantation at acupoint shows certain regulation on immune related indexes of lung cancer patients undergoing thoracoscopic surgery.

关 键 词：穴位埋线 支气管肺癌 胸腔镜手术 免疫调节 

分 类 号：R734.2[医药卫生—肿瘤]