电针对乳腺癌患者术后免疫功能抑制的改善作用临床研究  

Clinical study on improvement of electroacupuncture on postoperative immunosuppression in breast cancer patients

作　　者：高浩 陈曦[1] 雍玥 宋建钢[1] 王永强[1] 陈文婷[1] GAO Hao;CHEN Xi;YONG Yue;SONG Jiangang;WANG Yongqiang;CHEN Wenting(Department of Anesthesiology,Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China;Institute of Acupuncture and Anesthesia,Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China)

机构地区：[1]上海中医药大学附属曙光医院麻醉科,上海201203 [2]上海中医药大学附属曙光医院针麻研究所,上海201203

出　　处：《上海中医药大学学报》2022年第S01期84-87,共4页Academic Journal of Shanghai University of Traditional Chinese Medicine

基　　金：国家自然科学基金资助项目(81603450);上海中医药大学预算内项目(2019LK015)

摘　　要：目的:观察电针(EA)对乳腺癌患者术后患者免疫功能抑制的改善作用。方法:选择乳腺癌改良根治术的女性患者60例,随机分为对照组(CON组)和电针组(EA组),每组30例。EA组患者于术前、术中及术后给予EA干预,CON组患者不做处理。于术前、术后1 d、术后3 d观察患者CD4^(+)T、CD8^(+)T、CD4/CD8比值和NK细胞百分比的变化情况。结果:在术前和术后1 d,EA组免疫相关细胞(CD4^(+)T、CD8^(+)T、CD4^(+)/CD8^(+)和NK细胞)与CON组比较差异无统计学意义(P>0.05),在术后3 d,EA组免疫相关细胞(CD4^(+)T、CD4^(+)/CD8^(+))与CON组比较差异有统计学意义(P<0.05)。结论:EA能够通过增强机体的适应性免疫功能,改善乳腺癌患者的术后免疫功能抑制。Objective:To evaluate the improvement of electroacupuncture(EA)on immunosuppression in breast cancer patients after surgery.Methods:Sixty female patients underwent modified radical mastectomy for breast cancer were selected and randomly divided into control group(CON group)and electroacupuncture group(EA group),30 cases in both groups.Patients in the EA group were given EA intervention before,during and after surgery,while patients in the CON group were not intervened.The main observation indicators are the changes in the percentage of CD4^(+)T,CD8^(+)T,CD4^(+)/CD8^(+)ratio and NK cells in breast cancer patients before surgery,day 1 and day 3 after surgery.Results:Compared with the CON group,immune-related cells(CD4^(+)T,CD8^(+)T,CD4^(+)/CD8^(+)and NK cells)in the EA group has no statistically significant difference before surgery and day 1 after surgery(P>0.05).Day 3 after surgery,there was statistically significant difference in immune-related cells(CD4^(+)T,CD4^(+)/CD8^(+))between the EA group and the CON group(P<0.05).Conclusion:EA can improve the postoperative immunosuppression of breast cancer patients by enhancing the body's adaptive immune function.

关 键 词：电针 乳腺癌 免疫抑制 

分 类 号：R737.9[医药卫生—肿瘤]