双核素标记维生素B12吸收试验——104例测定结果分析  

A DUAL ISOTOPIC VITAMIN B12 ABSORPTION TEST: ANALYSIS OF 104 CASES

作　　者：袁济民[1] 

机构地区：[1]上海第二医科大学附属仁济医院核医学室

出　　处：《上海医学》1988年第11期645-648,共4页Shanghai Medical Journal

摘　　要：应用57Co和58Co分别标记内因子结合态和游离态维生素B12吸收试验,检测了萎缩性胃炎74例,胃手术后13例,回肠切除术后1例,晚期血吸虫病10例和正常人6例,其中31例恶性贫血呈维生素B12吸收障碍,有15例仅示58Co吸收低下,16例则示57Co和58Co均吸收不良,各为10.5±6.2%和4.22±2.78%(正常人为23.1±1.21%和24.1±2.66%);4例全胃切除者58Co吸收严重障碍(0.08±0.15%),而6例血清维生素B12水平低下的胃大部切除后病人维生素B12吸收正常。另同时检测血清维生索B12和内因子浓度、内因子抗体,据此分析和讨论了各种因素和维生素B12吸收障碍的关系。Application of intrinsic factor and vitamin B12 conjugation and free vitamin B12 respectively labeled with 57Co and 58Co to vitamin B12 absorption test in 98 patients suffering from different diseases and in 6 normal personsis reported.Among them 31 cases were found to have pernicious anemia with malabsorption of vitamin B12.Fifteen cases showed only lower absorption rate of 58Co,while other 16 were accompanied with malabsorption of 57Co and 58Co(10.5±5.2%and 4.22±2.78%respectively;23.±1.21%and 24.1±2.66%respectively in normals).Four patients showed severe malabsorption of 58Co after total gastrectomy,and 6 showd lower serum level of vitamin B12,but their absorption of vitamin B12 was normal after partial gastrectomy.In addition,the serum levels of vitamin B12,intrinsic and anti-intrinsic factors were also simultaneously determined,All the factors and their clinical implication are discussed.

关 键 词：内因子 游离态 恶性贫血 结合态 大细胞性贫血 吸收试验 抗体 核素标记 排出率 测定结果 萎缩性胃炎 维生素 

分 类 号：R73[医药卫生—肿瘤]