慢性粒细胞性白血病急性变33例临床分析  

ACUTE TRANSFORMATION OF CHRONIC MYELOCYTIC LEUKEMIA A CLINICAL STUDY OF 33 CASES

作　　者：彭永根 潘瑞彭 欧阳仁荣 

机构地区：[1]上海第二医学院附属第三人民医院血液组

出　　处：《上海医学》1981年第3期27-30,61-62,共6页Shanghai Medical Journal

摘　　要：本文对1970~1979年10年间住院确诊的慢性粒细胞性白血病急性变33例的临床资料作一分析,并结合文献对慢粒急变的早期诊断、慢粒急淋变、转归和治疗加以讨论.作者认为慢粒急变的早期诊断不能完全根据血象或骨髓象中原始+早幼粒细胞的百分率来决定,而应结合临床资料进行全面分析。慢粒急淋变者对长春新碱加强的松的疗效较好,缓解率较高。根据急变的细胞类型选择合适的治疗方案,对患者的预后似有密切关系.33 cases of acute transformation of chronic myeloeytic leukemia(CML)admitted from January 1970 to December 1979 were analysed.Early diagnosis,lymphoid metamorphosis,prognosis and treatment were discussed.The early diagnosis of CML in acute transforma-tion must be made on the bases of both the clinical manifestations and the percentage of blasts and promyelocytes found in the blood and bone marrow smears.The effect of the treatment varied with different cell type of blasts metamorphosis.In patients with CML in lymphoid metamorphosis,better results and higher remission rate could be obtained by the administration of vincristine-prednisone.

关 键 词：慢粒 长春新碱 早期诊断 急变期 急淋变 慢性粒细胞性白血病 慢性髓质性白血病 急性变 

分 类 号：R73[医药卫生—肿瘤]