帕金森疾病的相关视网膜表现  

Related retinal manifestations in Parkinson's disease

作　　者：王新钰 高丽芬 路晖[2] 宋文琦[2] 杨钰 WANG Xinyu;GAO Lifen;LU Hui;SONG Wenqi;YANG Yu(Weifang Medical College,Weifang 261053,Shandong,China;Ophthalmology Department,Zibo Central Hospital,Zibo 255000,Shandong,China)

机构地区：[1]潍坊医学院,山东潍坊261053 [2]淄博市中心医院眼科,山东淄博255000

出　　处：《山东大学耳鼻喉眼学报》2024年第2期156-162,共7页Journal of Otolaryngology and Ophthalmology of Shandong University

摘　　要：帕金森疾病是由α-突触核蛋白在神经系统中的异常沉积和多巴胺能神经的损伤引发运动迟缓、静止性震颤等运动症状的神经退行性疾病。由于视觉障碍在病程早期即可发现,视网膜的功能改变和结构改变可在帕金森疾病诊断和治疗策略中起到重要作用。综述探讨了帕金森病有关的的视网膜变化,如视网膜多巴胺能神经元数量减少,使用光学相干断层扫描测量的视网膜神经纤维层和黄斑变薄,视网膜电图中振幅降低和潜伏期缩短等解释帕金森病对视网膜的影响。本文认为帕金森患者视网膜异常可以作为早期评估帕金森病发病的潜在标志物,并有助于对患者进行疾病的分期,对于帕金森病的诊断和治疗策略具有重要意义。Parkinson's disease is a neurodegenerative disorder characterized by bradykinesia,resting tremor,and other symptoms caused by abnormalα-synuclein deposition in the nervous system and dopaminergic nerve damage.As visual impairments can be detected during the early stages,functional and structural changes in the retina can play an important role in diagnosis and treatment strategies for Parkinson's disease.This review examines the retinal changes associated with Parkinson's disease,such as a decreased number of retinal dopaminergic neurons,thinning of the retinal nerve fiber layer and macula(measured by using optical coherence tomography),and a decrease in amplitude and shortening of the latency period in electroretinograms,to explain the effects of Parkinson's disease on the retina.This paper concludes that retinal abnormalities in patients with Parkinson's can be used as a potential marker for early assessment of Parkinson's disease onset and can help to stage the disease,which is important for diagnosis and therapeutic strategies.

关 键 词：帕金森病 多巴胺 视网膜电生理 光学相干断层扫描血管成像 视网膜微血管 

分 类 号：R774.1[医药卫生—眼科]