肺癌患者胸外手术前治疗牙周基础疾病对预防术后肺炎发生的效果评价  

Effects of periodontal basic therapy on postoperative pneumonia in patients with lung cancer before thoracic surgery

作　　者：韩靖[1] 贾春玲[2,3] HAN Jing;JIA Chunling(Department of Stomatology,Jinan Maternity and Child Health Care Hospital,Jinan 250001,Shandong,China;Department of Oral Medicine,Qilu Hospital of Shandong University,Jinan 250012,Shandong,China;Institute of Stomatology,Shandong University,Jinan 250012,Shandong,China)

机构地区：[1]济南市妇幼保健院口腔科,山东济南250001 [2]山东大学齐鲁医院口腔内科,山东济南250012 [3]山东大学口腔医学研究所,山东济南250012

出　　处：《山东大学学报（医学版）》2022年第9期113-118,共6页Journal of Shandong University:Health Sciences

基　　金：山东省医药卫生科技发展计划(2014WS0141)

摘　　要：目的探讨术前牙周病基础治疗对行胸外科手术的肺癌伴牙周疾病者术后肺炎(POP)发生的影响。方法将符合纳入与排除标准、拟接受胸外科手术的肺癌伴牙周疾病患者,分为实验组和对照组。实验组术前行牙周病基础治疗,对照组保持患者原有口腔卫生习惯。两组人群均在术后随访满30 d,分析30 d内的POP发生率及有关因素。结果实验组(n=206)和对照组(n=190)基线特征一致。实验组POP发生率为2.91%,低于对照组14.21%(χ^(2)=16.52,P<0.001)。牙周病基础治疗可以预防POP的发生(OR=0.181,95%CI:0.078~0.411)。术前诊断为牙龈炎、牙周炎的患者,实验组POP发生率均低于对照组(P<0.05)。两组人群中均有随牙周疾病严重程度的增加,POP发生率升高的趋势(P<0.05)。无论行开胸术者(楔形切除、肺叶切除、肺段切除、袖状切除)还是行电视辅助胸腔镜手术者,实验组POP发生率均低于对照组(P<0.05)。结论术前牙周病基础治疗可以降低行胸外科手术的肺癌伴牙周疾病者POP发生率。Objective To investigate the effects of periodontal basic therapy on postoperative pneumonia(POP)in patients with lung cancer undergoing thoracic surgery.Methods Patients with lung cancer and periodontal disease who met the inclusion and exclusion criteria were divided into the experimental group and control group.The experimental group received periodontal basic therapy before thoracic surgery,while the control group maintained the oral hygiene habits.All subjects were followed up for 30 days,and the incidence of POP and related factors were analyzed.Results There were 206 cases in the experimental group and 190 cases in the control group.The incidence of POP in the experimental group was 2.91%,which was lower than that in the control group 14.21%(χ^(2)=16.52,P<0.001).Logistic regression results showed that periodontal basic therapy had a protective effect on POP(OR=0.181,95%CI=0.078-0.411).The incidence of POP in the experimental group was lower than that in the control group(P<0.05)in patients with gingivitis and periodontitis.In both groups,the incidence of POP increased with the severity of periodontal disease(P<0.05).The incidence of POP in the experimental group was significantly lower than that in the control group in those who underwent thoracotomy(wedge resection,lobectomy,segmental resection,sleeve resection)or video-assisted thoracoscopic surgery(P<0.05).Conclusion Periodontal basic therapy can reduce the incidence of POP in patients with lung cancer and periodontal disease before thoracic surgery.

关 键 词：牙周病基础治疗 肺癌 术后肺炎 临床试验 

分 类 号：R781.4[医药卫生—口腔医学] R734.2[医药卫生—临床医学]