石杉碱甲用于老年血管性痴呆对患者CDR水平及血清E2水平的影响  

Effects of huperzine A on CDR level and serum E2 level in patients with senile vascular dementia

作　　者：王建民[1] 郭小玲 崔雯静 刘姣姣 王丹 张彤 董秀芳[2] Wang Jianmin;Guo Xiaoling;Cui Wenjing;Liu Jiaojiao;Wang Dan;Zhang Tong;Dong Xiufang(Department of Neurology,Xingtai People's Hospital,Xingtai,Hebei 054031;Department of Neurology,First Affiliated Hospital of Xingtai Medical College,Xingtai,Hebei 054000)

机构地区：[1]邢台市人民医院神经内科,河北邢台054031 [2]邢台医学高等专科学校第一附属医院神经内科,河北邢台054000

出　　处：《生命科学仪器》2023年第6期143-146,共4页Life Science Instruments

摘　　要：目的探讨石杉碱甲用于老年血管性痴呆对患者CDR水平及血清E2水平的影响。方法选取2020年12月-2022年12月我院104例的老年血管性痴呆患者,分为两组,其中对照组选择长春西汀治疗,而研究组是石杉碱甲治疗。结果研究组的治疗效果比对照组更好(P<0.05);研究组的临床血液流变学指标比对照组更优(P<0.05);研究组的血清E2水平以及P300潜伏期与波幅情况比对照组更好(P<0.05);研究组的不良反应发生率比对照组更低(P<0.05)。结论石杉碱甲治疗老年血管性痴呆可以有效改善机体的痴呆症状,恢复认知功能,调节血清E2水平,并改善机体血液流变学指标,从而有效提高日常生活能力,应该推广。Objective:To investigate the effects of huperzine A on the level of CDR and serum E2 in patients with senile vascular dementia.Methods:104 patients with senile vascular dementia in our hospital from December 2020 to December 2022 were selected and divided into two groups.The control group was treated with vinpocetine,while the study group was treated with huperzine A.Results:The treatment effect of the study group was better than that of the control group(P<0.05).The clinical hemorheology index of the study group was better than that of the control group(P<0.05).The level of serum E2 and the latency and amplitude of P300 in the study group were better than those in the control group(P<0.05);The incidence of adverse reactions in the study group was lower than that in the control group(P<0.05).Conclusion:Huperzine A in the treatment of senile vascular dementia can effectively improve dementia symptoms,restore cognitive function,regulate serum E2 level,and improve hemorheology indexes,so as to effectively improve the ability of daily life,and should be popularized.

关 键 词：长春西汀 石杉碱甲 老年血管性痴呆 CDR水平 血清E2水平 

分 类 号：R749.053[医药卫生—神经病学与精神病学]