银杏酮酯分散片治疗脑梗死的成本及效果分析:一项基于真实世界的队列研究  

Cost and efficacy analysis of ginkgo ketoester dispersible tablets in the treatment of cerebral infarction:a real world cohort study

作　　者：周琼[1] 安阳方 王彪 曾军 喻利 Zhou Qiong;An Yangfang;Wang Biao;Zeng Jun;Yu Li(Department of Neurology,Yiyang Central Hospital,Yiyang 413000 Hunan,China)

机构地区：[1]益阳市中心医院神经内科,湖南益阳413000

出　　处：《生命科学仪器》2023年第4期53-56,共4页Life Science Instruments

基　　金：益阳市中心医院科研计划项目(2022YB09)

摘　　要：目的:分析研究银杏酮酯分散片治疗脑梗死的成本及效果。方法:选取2021年7月-2022年7月期间在我院接受治疗的400例脑梗死患者作为本次研究对象,采用数字随机法将其分为对照组和研究组(n=200)。对照组给予常规药物治疗,在此基础上研究组采用银杏酮酯分散片治疗。对比两组治疗成本、临床疗效,治疗前后神经功能、生活能力、认知水平评分、Hcy、SOD、hs-CRP水平、不良反应率。结果:治疗前,两组MOCA、NIHSS、BI评分,差异无统计学意义(P>0.05);治疗后,两组MOCA、NIHSS、BI评分均有显著改善,且研究组更为明显,差异具有统计学意义(P<0.05);治疗前,两组hs-CRP、Hcy、SOD水平对比,差异无统计学意义(P>0.05);治疗后,两组Hcy、hs-CRP水平有所降低,SOD水平有所升高,且研究组变化更为明显,差异具有统计学意义(P<0.05);研究组总有效率为91.00%显著优于对照组73.00%,差异具有显著性;研究组成本-效果为13316.95低于对照组的16656.16元;对照组总不良反应率为15.00%,研究组为16.00%,差异无统计学意义(χ2=0.076,P=0.782)。结论:银杏酮酯分散片能有效降低脑梗死患者血清炎症因子水平,提高其神经功能、生活能力、认知水平,随着治疗效果的增加,药品成本不一定上升,且无明显不良反应增加,临床应用价值高。Objective:To analyze and study the cost and efficacy of ginkgo biloba ketone ester dispersible tablets in the treatment of cerebral infarction.Method:A total of 400 patients with cerebral infarction admitted to me between July 2021 and July 2022 were selected as the study subjects.They were randomly divided into a control group and a study group using a digital randomization method(n=200).The control group was treated with conventional drugs,which were combined with ginkgo biloba ester dispersible tablets.Compare the neurological function,life ability,cognitive level score,serum indicators,clinical efficacy,and adverse reaction rate between two groups before and after treatment.Result:Before treatment,there was no statistically significant difference in MOCA,NIHSS,and BI scores between the two groups(P>0.05);After treatment,both groups showed significant improvements in MOCA,NIHSS,and BI scores,and the study group showed more significant differences with statistical significance(P<0.05);Before treatment,there was no statistically significant difference in hs CRP,Hcy,and SOD levels between the two groups(P>0.05);After treatment,the levels of Hcy and hs CRP in the two groups decreased,while the levels of SOD increased.The changes in the study group were more significant,and the difference was statistically significant(P<0.05);The total effective rate of the research group was 91.00%,which was significantly better than that of the control group at 73.00%,and the difference was statistically significant(P<0.05);The cost-effectiveness of the research group was 13316.95 yuan,lower than the control group's 16656.16 yuan;The total adverse reaction rate in the control group was 15.00%,while in the study group it was 16.00%,with no statistically significant difference(χ2=0.076,P=0.782).Conclusion:Ginkgo biloba ketone ester dispersible tablets can effectively reduce the levels of serum inflammatory factors in patients with cerebral infarction,improve their neurological function,life ability,and cognitive level.With the inc

关 键 词：脑梗死 银杏酮酯分散片 治疗成本 临床疗效 

分 类 号：R749.053[医药卫生—神经病学与精神病学]