TDP-43在肌萎缩侧索硬化症中发病机制的研究  

The pathogenesis of TDP-43 in amyotrophic lateral sclerosis

作　　者：潘昊 荆玮 王呈蕙 单悦童 费智敏[1] PAN Hao;JING Wei;WANG Chenghui;SHAN Yuetong;FEI Zhimin(Department of Neurosurgery,Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China;Department of Neurology,Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China)

机构地区：[1]上海中医药大学附属曙光医院神经外科,上海201203 [2]上海中医药大学附属曙光医院神经内科,上海201203

出　　处：《神经病学与神经康复学杂志》2023年第2期44-50,共7页Journal of Neurology and Neurorehabilitation

摘　　要：肌萎缩侧索硬化症(amyotrophic lateral sclerosis,ALS)是目前无有效治疗的一种神经退行性疾病,其发病机制不清。近期研究发现反式激活应答DNA结合蛋白43(transactive response element DNA binding protein-43,TDP-43)在包括ALS、额颞叶痴呆等神经退行性疾病中起重要作用。本文总结了近10年来对TDP-43结构的最新认识及其在神经退行性疾病发病机制的作用与潜在的治疗靶点,以期为中西医结合诊治ALS提供一定的基础研究依据。Amyotrophic lateral sclerosis(ALS)is a neurodegenerative disease that currently has no effective treatment,and its pathogenesis is unclear.Recent studies have found that transactive response element DNA binding protein-43(TDP-43)plays an important role in neurodegenerative diseases including ALS and frontotemporal dementia.This article summarizes the latest understanding of the structure of TDP-43 in the past decade,its role in the pathogenesis of neurodegenerative diseases,and potential therapeutic targets,in order to provide a basic research basis for the integrated diagnosis and treatment of ALS with Chinese and Western medicine.

关 键 词：肌萎缩侧索硬化症 反式激活应答DNA结合蛋白43 谷氨酸受体 发病机制 治疗策略 

分 类 号：R744.8[医药卫生—神经病学与精神病学]