山东省中晚期结直肠癌患者生命质量现状及影响因素分析  

Quality of life status and influencing factors of patients with middle and advanced colorectal cancer in Shandong Province

作　　者：孙康宁 张秀杰[3] 王春辉 马海燕 吴冬梅[2] 孙海娅[2] 刘冰[2] 朱凤华[6] 王文军 SUN Kangning;ZHANG Xiujie;WANG Chunhui;MA Haiyan;WU Dongmei;SUN Haiya;LIU Bing;ZHUFenghua;WANG Wenjun(School of Public Health,North China University of Science and Technology,Tangshan 063210,China;School of Nursing,Jining Medical University,Jining 272002,China;Cardiovascular Second Department,Jinan Fourth People's Hospital,Jinan 250031,China;Health Emergency Office,Qingdao Northern District Center for Disease Control and Prevention,Qingdao 266012,China;Chronic Non-communicable Disease Prevention and Control Department,Chengyang District Center for Disease Controland Prevention,Qingdao 266108,China;Department of Digestive Oncology,Affiliated Hospital of Jining Medical College,Jining 272007,China)

机构地区：[1]华北理工大学公共卫生学院,河北唐山063210 [2]济宁医学院护理学院,山东济宁272002 [3]济南市第四人民医院心血管内二科,山东济南250031 [4]青岛市市北区疾病预防控制中心卫生应急办公室,山东青岛266012 [5]青岛市城阳区疾病预防控制中心慢性非传染性疾病防制科,山东青岛266108 [6]济宁医学院附属医院消化肿瘤科,山东济宁272007

出　　处：《中华肿瘤防治杂志》2023年第15期897-903,共7页Chinese Journal of Cancer Prevention and Treatment

基　　金：北京爱谱癌症患者关爱基金会

摘　　要：目的探讨中晚期结直肠癌患者生命质量现状及相关的影响因素,为进一步提高患者的生命质量提供科学依据。方法选取2019年9月-2021年12月山东省青岛、济南、济宁、聊城和枣庄市11所三级综合医院收治的889例中晚期结直肠癌患者开展问卷调查,回收有效问卷881份,有效问卷回收率99.10%;其中结肠癌383例,直肠癌498例。采用本土化的结直肠癌患者生命质量测定量表(FACT-C量表;第四版)评估患者生命质量,并分析患者生命质量影响因素。结果山东省中晚期结直肠癌患者生命质量总分为(132.96±27.87)分,社会/家庭状况、功能状况、生理状况和情感状况总分分别为(22.70±5.89)、(24.26±8.00)、(52.53±10.13)和(33.52±9.27)分,各领域及总体生命质量均处于中上水平。生命质量总分在职业(F=3.492,P=0.008)、确诊时是否转移(t=2.242,P=0.025)、是否接受基因检测(t=2.536,P=0.011)以及确诊时间长短(F=5.079,P=0.006)等方面差异有统计学意义。多因素分析显示,临床分期为Ⅳ期(t=-6.439,P<0.001)、无转移(t=-2.929,P=0.003)、做过基因检测(t=3.578,P<0.001)、确诊时间≥5年(t=-2.061,P=0.040)、职业为商业/个体(t=2.292,P=0.022)、职业为工人/农民(t=2.633,P=0.009)和职业为管理人员(t=2.390,P=0.017)是结直肠癌患者生命质量的主要影响因素。结论山东省中晚期结直肠癌患者生命质量各领域及总体得分均处于中上水平,社会人口学和临床特征是其主要影响因素,应针对不同患者采取不同的干预措施,以提高生命质量。Objective To explore the current status and related influencing factors of quality of life in patients with advanced colorectal cancer,and to provide a scientific basis for further improving the quality of life of patients.Methods A questionnaire survey was conducted on 889patients with middle and advanced colorectal cancer admitted to 11tertiary comprehensive hospitals in Qingdao,Jinan,Jining,Liaocheng,and Zaozhuang in Shandong Province from September 2019to December 2021.A total of 881valid questionnaires were collected,with a recovery rate of 99.10%;Among them,there were 383cases of colon cancer and 498cases of rectal cancer.We evaluated the quality of life of patients with colorectal cancer using the localized colorectal cancer patient quality of life measurement scale(FACT-C Scale)(Fourth Edition)and analyzed the influencing factors of patient quality of life.Results The total score of quality of life for patients with middle to advanced colorectal cancer in Shandong Province was(132.96±27.87)points,while the total scores for social/family status,functional status,physiological status,and emotional status were(22.70±5.89),(24.26±8.00),(52.53±10.13),and(33.52±9.27)points,respectively.All fields and overall quality of life were at an above average level.The total score of quality of life showed statistical significance in terms of occupation(F=3.492,P=0.008),metastasis at diagnosis(t=2.242,P=0.025),genetic testing(t=2.536,P=0.011),and the time length of diagnosis(F=5.079,P=0.006).Multivariate analysis showed that the clinical staging at stage IV(t=-6.439,P<0.001),no metastasis(t=-2.929,P=0.003),genetic testing(t=3.578,P<0.001),diagnosis time≥5years(t=-2.061,P=0.040),and occupation as commercial/individual(t=2.292,P=0.022),occupation as worker/farmer(t=2.633,P=0.009)and occupation as management personnel(t=2.390,P=0.017)were the main influencing factors on the quality of life of colorectal cancer patients.Conclusions The quality of life of patients with advanced colorectal cancer in Shandong Province is

关 键 词：结直肠癌 山东省 生命质量评价 职业 疾病分期 

分 类 号：R735.3[医药卫生—肿瘤]