中国人群先天性白内障危险因素的Meta分析  

Meta analysis of risk factors for congenital cataract in Chinese population

作　　者：石丽娟 李丽 石福艳[3] 李满梅[2] 王雪[2] 吴志鸿[2] SHI Lijuan;LI li;SHI Fuyan;LI Manmei;WANG Xue;and WU Zhihong(Department of Ophthalmology,School of Clinical Medicine,Weifang Medical College,Weifang 261053,China;Senior Department of Ophthalmology,the Third Medical Center of PLA General Hospital,Beijing 100039,China;Department of Health Statistics,School of Clinical Medicine,Weifang Medical College,Weifang 261053,China)

机构地区：[1]潍坊医学院临床医学院眼科学教研室,261053 [2]解放军总医院第三医学中心眼科医学部,北京100039 [3]潍坊医学院公共卫生学院卫生统计学教研室,261053

出　　处：《武警医学》2022年第12期1033-1037,共5页Medical Journal of the Chinese People's Armed Police Force

基　　金：北航-首医大数据精准医疗高精尖创新中心同仁分中心开放基金项目(BHTR-KFJJ-202017)

摘　　要：目的探讨中国人群先天性白内障的危险因素,为降低先天性白内障的发生率提供依据。方法检索CNKI、VIP、WanFang Data、Pubmed和Embase数据库,收集以上各数据库从建库至2021-11-30公开发表的有关先天性白内障危险因素的文献,运用RevMan5.4软件行Meta分析。结果本研究共纳入文献6篇,累计病例650例,对照1353例。Meta分析结果显示,中国人群先天性白内障的危险因素主要有:出生后给氧治疗(OR=5.50,95%CI:1.66~18.20)、家族遗传史(OR=6.97,95%CI:2.76~17.62)、孕期感染(OR=2.06,95%CI:1.38~3.06)、孕期营养状况不佳(OR=2.55,95%CI:1.17~5.56)、孕期服用药物(OR=4.49,95%CI:1.74~11.59)、患缺血缺氧性脑病(OR=6.42,95%CI:1.35~30.53)、早产(OR=2.14,95%CI:1.28~3.60)、低出生体重(OR=4.04,95%CI:2.11~7.75)、外周血血清补体C_(3)水平下降(OR=1.04,95%CI:1.02~1.07)以及CRYAA和CRYAB基因单核苷酸多态性:CRYAArs7278468 GT+TT等位基因(OR=6.03,95%CI:1.27~28.53)、CRYABrs370803064 AA+GA等位基因(OR=5.81,95%CI:1.57~21.56)、CRYABrs387907338 TT+TC等位基因(OR=2.47,95%CI:1.34~4.58)、CRYAB基因TA单倍型(OR=1.80,95%CI:1.10~2.95)。结论出生后给氧治疗、孕期感染、家族遗传史、孕期营养状况不佳、孕期服用药物、出生后诊断为缺血缺氧性脑病、早产、低出生体重、外周血血清补体C_(3)水平下降、CRYAA和CRYAB基因单核苷酸多态性为先天性白内障发病的重要危险因素。Objective To explore the risk factors of congenital cataracts in Chinese population.Methods CNKI,VIP,WanFang Data,Pubmed and Embase databases were searched from inception to November 30th,2021.Meta-analysis was conducted with RevMan5.4 software.Results Six articles were included,with a total of 650 cases and 1353 controls.The meta-analysis results showed that the risk factors for congenital cataract in the Chinese population were as follows,oxygen therapy after birth(OR=5.50,95%CI:1.66-18.20),family genetic history(OR=6.97,95%CI:2.76-17.62),infections during pregnancy(OR=2.06,95%CI:1.38-3.06),poor nutritional status during pregnancy(OR=2.55,95%CI:1.17-5.56),medications during pregnancy(OR=4.49,95%CI:1.74-11.59),suffering from ischemic hypoxic encephalopathy(OR=6.42,95%CI:1.35-30.53),premature delivery(OR=2.14,95%CI:1.28-3.60),low birth weight(OR=4.04,95%CI:2.11-7.75),peripheral blood serum complement C_(3)level decreased(OR=1.04,95%CI:1.02-1.07),CRYAA and CRYAB gene single nucleotide polymorphism:CRYAArs7278468 GT+TT allele(OR=6.03,95%CI:1.27-28.53),CRYABrs370803064 AA+GA allele(OR=5.81,95%CI:1.57-21.56),CRYABrs387907338 TT+TC allele(OR=2.47,95%CI:1.34-4.58),and CRYAB gene TA haplotype(OR=1.80,95%CI:1.10-2.95).Conclusions Congenital cataract is influenced by many factors,among which drug use during pregnancy,low birth weight,hypoxic ischemic encephalopathy and postnatal oxygen therapy are the most influential factors.

关 键 词：中国人 先天性白内障 发病 危险因素 META分析 

分 类 号：R776.1[医药卫生—眼科]