清热解毒通腑汤结合甲硝唑注射液对急性阑尾炎患者血清CRP、IL-6及TNF-α水平影响  

Effect of Qingre Jiedu Tongfu Decoction(清热解毒通腑汤)Combined with Metronidazole Injection on Serum CRP,IL-6 and TNF-αLevels in Patients with Acute Appendicitis

作　　者：高伊菲 高舸 王江洪 GAO Yifei;GAO Ge;WANG Jianghong(Guangxi Medical University,Nanning 530021,Guangxi,China;Fushun Central Hospital Affiliated to China Medical University,Fushun 113006,Liaoning,China;Fushun Traditional Chinese Medical Hospital,Fushun 113006,Liaoning,China)

机构地区：[1]广西医科大学,广西南宁530021 [2]中国医科大学附属抚顺市中心医院,辽宁抚顺113006 [3]抚顺市中医院,辽宁抚顺113006

出　　处：《辽宁中医药大学学报》2021年第10期217-220,共4页Journal of Liaoning University of Traditional Chinese Medicine

摘　　要：目的探讨清热解毒通腑汤结合甲硝唑注射液对急性阑尾炎患者血清C反应蛋白(CRP)、白介素6(IL-6)及肿瘤坏死因子α(TNF-α)水平的影响。方法以2018年8月—2019年5月中国医科大学附属抚顺市中心医院收治的急性阑尾炎患者75例为研究对象,依据治疗方法的不同分为治疗组(n=39例)和对照组(n=36例),对照组采用甲硝唑注射液治疗,治疗组采用清热解毒通腑汤结合甲硝唑注射液治疗。两组分别按疗程治疗4周。比较两组治疗前后中医证候积分变化,体温恢复正常时间,腹痛及压痛减轻时间,血清CRP、IL-6及TNF-α水平变化,白细胞计数和阑尾周围积液以及临床疗效。结果治疗组临床疗效高于对照组(P<0.05);两组治疗后腹痛、恶心呕吐、纳差和体温等中医证候积分较治疗前降低,且治疗组降低幅度优于对照组(P<0.05);两组治疗后血清炎性因子CRP、IL-6和TNF-α水平较治疗前降低,且治疗组降低幅度优于对照组(P<0.05);两组治疗后白细胞计数和阑尾周围积液较治疗前降低,且治疗组低于对照组(P<0.05);治疗组治疗后腹痛减轻时间、压痛减轻时间和体温恢复正常时间低于对照组(P<0.05)。结论清热解毒汤联合甲硝唑注射液治疗单纯性急性阑尾炎患者疗效显著,可改善急性单纯性阑尾炎患者的临床症状,在促进快速康复方面有显著疗效,值得临床进一步研究探讨。Objective To investigate the effect of Qingre Jiedu Tongfu Decoction(清热解毒通腑汤)combined with Metronidazole Injection on serum CRP,IL-6 and TNF-αlevels in patients with acute appendicitis.Methods 75 patients with acute appendicitis in Fushun central hospital affiliated to China medical university from August 2018 to May 2019 were selected as the research objects and divided into treatment group(n=39)and control group(n=6)according to different treatment methods.The control group was treated with Metronidazole Injection,and the treatment group was treated with Qingre Jiedu Tongfu Decoction combined with Metronidazole Injection.The two groups were treated for 4 weeks.The changes of TCM syndrome score before and after treatment were compared between the two groups;the recovery time of body temperature,abdominal pain and tenderness relief time after treatment were compared between the two groups;the changes of serum CRP,IL-6 and TNF-αlevels before and after treatment were compared between the two groups;the white blood cell count and periappendiceal effusion before and after treatment were compared between the two groups,and the therapeutic effect of the two groups was compared.Results The curative effect of the treatment group was higher than that of the control group(P<0.05);the scores of abdominal pain,nausea and vomiting,anorexia and body temperature of the two groups after treatment were lower than those before treatment,and the TCM symptom score of the treatment group was lower than that of the control group(P<0.05);the levels of serum inflammatory factors CRP,IL-6 and TNF-αof the two groups after treatment were lower than those before treatment,and the levels of serum CRP,IL-6 and TNF-αof the treatment group were lower than those before treatment In the control group(P<0.05);the white blood cell count and periappendiceal effusion of the two groups after treatment were lower than those before treatment,and the white blood cell count and periappendiceal effusion after treatment were lower than tho

关 键 词：急性阑尾炎 清热解毒通腑汤 甲硝唑注射液 炎症因子 

分 类 号：R574.61[医药卫生—消化系统]