The role of blood oxygenation level-dependent functional magnetic resonance imaging(BOLD-fMRI) combined with diffusion tensor imaging(DTI) in surgery for tumors involving motor pathways  

作　　者：Chaoqun Lin Lukui Chen 

机构地区：[1]School of Medicine,Southeast University,Nanjing 210009,Jiangsu,China [2]Department of Neurosurgery,Cancer Center,Integrated Hospital of Traditional Chinese Medicine,Southern Medical University,Guangzhou 510515,Guangdong,China

出　　处：《Brain Science Advances》2019年第3期169-177,共9页神经科学（英文）

基　　金：supported by the National Natural Science Foundation of China(No.81671819).

摘　　要：Objective:Blood oxygenation level-dependent functional magnetic resonance imaging(BOLD-fMRI)in combination with diffusion tensor imaging(DTI)can clearly show the specific relationship between brain tumors and motor pathways.The purpose of this study was to investigate the role of this combination in surgery for brain tumors involving motor pathways.Methods:From September 2018 to March 2019,preoperative BOLD-fM RI and DTI examinations were performed in patients with brain tumors involving motor pathways who were being treated in a neurosurgery department.The patients were divided into two groups according to the combined examination results.In one group,the motor pathways were intact;in the other,motor pathways were infiltrated by tumors.The surgical plan was total resection of the tumor as far as possible and with no damage to the motor pathway.The preoperative and postoperative motor dysfunction and the rate of total resection in the two groups were compared.Results:Of the 20 patients with intact motor pathways,15 had normal preoperative motor function,and 5 had preoperative motor dysfunction;of those 5 patients,3 exhibited postoperative aggravation of motor dysfunction.Total excision was performed in 16 patients with intact motor pathways and incomplete excision in 4.Of the 22 patients with motor pathway infiltration,8 had normal preoperative motor function and 14 had preoperative motor dysfunction;of those14,10 exhibited a postoperative increase in motor dysfunction.Total excision was performed in 8 patients with infiltrated motor pathways and incomplete excision in 14.Statistical analysis showed that there were significant differences between the two groups in preoperative motor function,postoperative changes in motor function,and total surgical resection rate(all p<0.05).Conclusions:First,whether tumors invade the motor pathway is an important factor affecting the degree of preoperative motor dysfunction.Second,the risk for postoperative motor dysfunction was lower in patients with intact motor pathways thanObjective: Blood oxygenation level-dependent functional magnetic resonance imaging(BOLD-fMRI) in combination with diffusion tensor imaging(DTI) can clearly show the specific relationship between brain tumors and motor pathways. The purpose of this study was to investigate the role of this combination in surgery for brain tumors involving motor pathways. Methods: From September 2018 to March 2019, preoperative BOLD-fM RI and DTI examinations were performed in patients with brain tumors involving motor pathways who were being treated in a neurosurgery department. The patients were divided into two groups according to the combined examination results. In one group,the motor pathways were intact; in the other, motor pathways were infiltrated by tumors. The surgical plan was total resection of the tumor as far as possible and with no damage to the motor pathway.The preoperative and postoperative motor dysfunction and the rate of total resection in the two groups were compared. Results: Of the 20 patients with intact motor pathways, 15 had normal preoperative motor function, and 5 had preoperative motor dysfunction; of those 5 patients, 3 exhibited postoperative aggravation of motor dysfunction. Total excision was performed in 16 patients with intact motor pathways and incomplete excision in 4. Of the 22 patients with motor pathway infiltration, 8 had normal preoperative motor function and 14 had preoperative motor dysfunction; of those14, 10 exhibited a postoperative increase in motor dysfunction.Total excision was performed in 8 patients with infiltrated motor pathways and incomplete excision in 14. Statistical analysis showed that there were significant differences between the two groups in preoperative motor function, postoperative changes in motor function,and total surgical resection rate(all p < 0.05). Conclusions: First, whether tumors invade the motor pathway is an important factor affecting the degree of preoperative motor dysfunction. Second, the risk for postoperative motor dysfunction was lower in patients

关 键 词：COGNITIVE function MONTREAL COGNITIVE Assessment Scale CEREBROSPINAL fluid drainage 

分 类 号：R445.2[医药卫生—影像医学与核医学] R739.41[医药卫生—诊断学]