伴甲状腺抗体升高的脑梗死患者罹患糖尿病风险增高  

Patients with cerebral infarction accompanied by elevated thyroid antibodies have an increased risk of diabetes.

作　　者：余爱勇 赵迎春[1] 陈晟[2] 彭亮 娄晓丽[4] 孙建军[5] 赵玉武[6] Yu Aiyong;Zhao Yingchun;Chen Sheng;Peng Liang;Lou Xiaoli;Sun Jianjun;Zhao Yuwu(Department of Neurology,the Songjiang Hospital Affiliated to Shanghai Jiaotong University School of Medicine.Shanghai 201699,China)

机构地区：[1]上海交通大学医学院附属松江医院(筹)神经内科,上海201699 [2]上海交通大学医学院附属瑞金医院神经内科 [3]上海交通大学医学院附属松江医院(筹)检验科,上海201699 [4]上海交通大学医学院附属松江医院(筹)中心实验室,上海201699 [5]上海市公共卫生临床中心感染与免疫科 [6]上海交通大学附属第六人民医院神经内科

出　　处：《脑与神经疾病杂志》2020年第10期633-637,共5页Journal of Brain and Nervous Diseases

基　　金：松江区科学技术攻关项目(15SJGG30)

摘　　要：目的揭示甲状腺抗体升高的脑梗死的并发疾病特征,指导临床。方法选择甲状腺抗体正常合并脑梗死患者共143例,甲状腺抗体升高合并脑梗死组患者共计86例。比较两组患者发生脑梗死的特征,同时运用Logistic回归法分析其危险因素。结果甲状腺抗体升高组发生脑梗死的比例低于甲状腺抗体正常组(39.63%vs.67.14%,χ^2=5.808,P=0.016)。在脑梗死中,甲状腺抗体升高组患者伴随糖尿病的病例(39.53%vs.20.28%,χ^2=9.984,P=0.002)高于甲状腺抗体正常组。Logistic回归分析结果,性别(OR=3.966,95%CI=1.911~8.231,P=0.000)、糖尿病(OR=2.858,95%CI=1.497~5.457,P=0.001)是脑梗死合并甲状腺抗体升高者的独立危险因素。结论甲状腺抗体升高者合并脑梗死的比例低,脑梗死合并甲状腺抗体升高者罹患糖尿病风险高。遇到甲状腺抗体升高的脑梗死患者,需要排除合并潜在隐匿糖尿病的可能。Objective In order to reveal the relationship between elevated thyroid antibodies and cerebral infarction,the risk factors were also analyzed.Methods A total of 143 patients with completely normal thyroid antibodies and 86 patients with elevated thyroid antibodies were selected.The characteristics of cerebral infarction between the two groups of patients were compared,and the risk factors were analyzed using Logistic regression.Results The rate of cerebral infarction in the group with elevated thyroid antibodies was lower than that in the group with normal thyroid antibodies(39.63%vs.48.11%,χ^2=5.808,P=0.016).In cerebral infarction,cases with diabetes mellitus(39.53%vs.20.28%,χ^2=9.984,P=0.002)in patients with elevated thyroid antibody group were higher than those with normal thyroid antibody group.Logistic regression analysis results showed that gender(OR=3.966,95%CI=1.911-8.231,P=0.000),diabetes(OR=2.858,95%CI=1.497-5.457,P=0.001)were independent risk factors.Conclusion The proportion of patients with elevated thyroid antibodies with cerebral infarction is low,and those with cerebral infarction and elevated thyroid antibodies have a higher risk of diabetes,cerebral infarction with elevated thyroid antibodies.

关 键 词：甲状腺抗体 脑梗死 糖尿病 

分 类 号：R743.33[医药卫生—神经病学与精神病学] R587.2[医药卫生—临床医学]