非酒精性脂肪性肝病合并肝纤维化与心血管疾病常见危险因素的关系  

Relationship between non-alcoholic fatty liver disease with liver fibrosis and common risk factors of cardiovascular diseases

作　　者：师强伟 于蕊[2] Shi Qiangwei;Yu Rui(Department of Cardiovascular Internal Medicine,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China)

机构地区：[1]郑州大学第一附属医院心内科,郑州450052 [2]郑州大学第一附属医院消化内科,郑州450052

出　　处：《临床内科杂志》2022年第11期745-747,共3页Journal of Clinical Internal Medicine

基　　金：河南省自然科学基金资助项目(202300410408)

摘　　要：目的探讨非酒精性脂肪性肝病(NAFLD)合并肝纤维化与心血管疾病常见危险因素的关系。方法根据是否合并肝纤维化,将545例NAFLD患者分为合并肝纤维化组(92例)及无肝纤维化组(453组)。收集两组患者的临床资料并进行比较,采用二元logistic回归分析评估肝纤维化与心血管疾病危险因素之间的关系。结果合并肝纤维化组年龄、高密度脂蛋白胆固醇(HDL-C)水平、BMI、高血压病及糖尿病的患者比例均高于无肝纤维化组,而总胆固醇(TC)水平低于无肝纤维化组(P<0.05)。二元logistic回归分析结果显示,肝纤维化是NAFLD患者肥胖(OR=2.97,95%CI 2.42~3.50)、低HDL-C血症(OR=2.33,95%CI 1.88~2.81)、高血压病(OR=1.93,95%CI 1.39~2.44)及糖尿病(OR=3.66,95%CI 2.54~4.77)的独立危险因素(P<0.05),引入BMI或CAP进行校正后OR值有所下降,但显著性依然存在。结论NAFLD患者合并肝纤维化与心血管疾病常见危险因素(如肥胖、低HDL-C血症、高血压病及糖尿病)相关。Objective To investigate the relationship between non-alcoholic fatty liver disease(NAFLD)complicated with liver fibrosis and common risk factors of cardiovascular diseases.MethodsAccording to whether they were complicated with liver fibrosis,545 patients with NAFLD were divided into complicated with liver fibrosis group(92 cases)and non-liver fibrosis group(453 cases).Clinical data of the two groups were collected and compared.Binary logistic regression analysis was used to evaluate the relationship between liver fibrosis and risk factors of cardiovascular disease.Results Age,high-density lipoprotein cholesterol(HDL-C)level,BMI,the proportion of patients with hypertension and diabetes mellitus in complicated with liver fibrosis group were higher than those in non-liver fibrosis group,while total cholesterol(TC)was lower than that in non-liver fibrosis group(P<0.05).Binary logistic regression analysis results show that liver fibrosis were independent risk factors of patients with NAFLD of obese(OR=2.97,95%CI 2.42-3.50),low HDL-C(OR=2.33,95%CI 1.88-2.81),hypertension(OR=1.93,95%CI 1.39-2.44),and diabetes mellitus(OR=3.66,95%CI 2.54-4.77)(P<0.05).The OR value decreased after adjustion of BMI or CAP,but the significance still existed.Conclusion Liver fibrosis in NAFLD patients is associated with common risk factors for cardiovascular diseases(such as obesity,low HDL-C,hypertension and diabetes mellitus).

关 键 词：非酒精性脂肪性肝病 肝纤维化 心血管疾病 危险因素 

分 类 号：R575[医药卫生—消化系统] R54[医药卫生—内科学]