肝硬化患者胃肠激素水平与消化道症状积分的相关分析  

Correlation analysis between gastrointestinal hormone level and gastrointestinal symptom scores in patients with liver cirrhosis

作　　者：鲁申奥 陈艳 靳江 郭虹[1] 张英剑[1] 刘晓敏[1] Lu Shen’ao;Chen Yan;Jin Jiang;Guo Hong;Zhang Yingjian;LiuXiaomin(Department of Gastrdogy,the First Affiliated Hospital of Henan University of Science and Technology,Luoyang 471003,China)

机构地区：[1]河南科技大学临床医学院河南科技大学第一附属医院消化内科,河南洛阳471003

出　　处：《临床内科杂志》2022年第7期453-456,共4页Journal of Clinical Internal Medicine

基　　金：河南省医学科技攻关计划项目(201504039)

摘　　要：目的探讨肝硬化患者胃肠激素水平与消化道症状积分的关系。方法收集肝硬化患者95例(肝硬化组),并根据Child-Pugh肝功能分级将其分为肝功能A级组45例、肝功能B级组23例、肝功能C级组27例,纳入同期健康体检者40例为对照组(NC组)。收集所有受试者的一般资料及胃肠激素水平、肝硬化患者消化道症状积分并分组进行比较。相关分析评估采用pearson相关分析。结果肝硬化组患者血清胃泌素(GAS)、血管活性肠肽(VIP)水平均明显高于NC组,胃动素(MTL)水平低于NC组;肝功能C级组患者血清GAS、VIP水平均高于肝功能A级组、B级组及NC组,但血清MTL水平均低于肝功能A级组及NC组;不同肝功能分级的3组患者血清GAS水平均高于NC组,血清MIL水平均低于NC组,肝功能B级组、C级组患者血清VIP水平均高于NC组(P<0.05)。Pearson相关分析结果显示,肝硬化患者消化道症状积分、Child-Pugh肝功能分级与血清GAS、VIP水平呈负相关,与血清MIL水平呈负相关;肝硬化患者Child-Pugh肝功能分级与消化道症状积分呈正相关(P<0.05)。结论肝硬化患者胃肠激素水平的紊乱导致其胃肠功能障碍,进而影响消化道症状积分。以上变化与肝硬化病情的进展及肝功能损害程度密切相关。Objective To explore the relationship between gastrointestinal hormone levels and gastrointestinal symptom scores in patients with liver cirrhosis.Methods A total of 95 patients with liver cirrhosis were collected as liver cirrhosis group.According to Child-Pugh liver function classification,they were divided into liver function A group(45 cases),liver function B group(23 cases)and liver function C group(27 cases).Forty healthy subjects were included as the control group(NC group).General information,gastrointestinal hormone levels and gastrointestinal symptom scores of patients with liver cirrhosis were collected and compared in groups.Correlation analysis was evaluated by pearson correlation analysis.Results The levels of serum gastrin(GAS)and vasoactive intestinal peptide(VIP)in the liver cirrhosis group were significantly higher than those in the NC group,and the level of serum motilin(MTL)was lower than that in the NC group;the levels of serum GAS and VIP in grade C group were higher than those in grade A、B and NC group,but the levels of serum MTL were lower than those in grade A and NC group;the serum GAS level of 3 groups with different liver function grades was higher than that of NC group,the serum MIL level was lower than that of NC group,and the serum VIP level of patients with liver function grade B and C groups was higher than that of NC group(P<0.05).Gastrointestinal symptom scores and Child-Pugh liver function classification in patients with liver cirrhosis were positively correlated with serum GAS and VIP levels,and negatively correlated with serum MTL levels;Child-Pugh liver function classification was positively correlated with gastrointestinal symptom score in patients with liver cirrhosis(P<0.05).Conclusion The gastrointestinal dysfunction of patients with liver cirrhosis is caused by the disorder of gastrointestinal hormone level,which affects the change of gastrointestinal symptom score in patients with liver cirrhosis.These changes are closely related to the progression of liver cirrhosis

关 键 词：肝硬化 胃泌素 胃动素 血管活性肠肽 

分 类 号：R575.2[医药卫生—消化系统]