孕前父亲烟草暴露与6岁儿童智力水平的前瞻性队列研究  

A prospective cohort study on the association between paternal exposure to cigarette smoke prior to pregnancy and children′s intelligence at 6 years

作　　者：苏慧佳 纪红蕾 陈瑶 陈雅菲 苗茂华 袁伟 SU Hui-jia;JI Hong-lei;CHEN Yao;CHEN Ya-fei;MIAO Mao-hua;YUAN Wei(Shanghai Instruct and Service Center for Population and Family Development,NHC Key Lab.of Reproduction Regulation,Shanghai Institute for Biomedical and Pharmaceutical Technologies,Shanghai 200237,China;不详)

机构地区：[1]上海市生物医药技术研究院国家卫生健康委员会计划生育药具重点实验室,上海市人口和家庭计划指导服务中心,上海200237 [2]上海市生物医药技术研究院国家卫生健康委员会计划生育药具重点实验室

出　　处：《中国儿童保健杂志》2022年第11期1164-1168,1207,共6页Chinese Journal of Child Health Care

基　　金：国家科技部重点研发计划项目(2021YFC2701003);上海市卫生健康委员会课题(202104333);国家卫生健康委员会计划生育药具重点实验室创新能力专项资助(CX2022-OX)

摘　　要：目的评估孕前父亲烟草暴露对6岁儿童智力的影响,为指导优生优育服务提供循证依据。方法本研究纳入2012年建立的上海闵行出生队列的530对母子,在孕妇建大卡时通过结构式问卷获得了孕前3个月父亲烟草暴露情况,在儿童6岁时利用第四版《儿童韦氏智力测试量表》中文版简版考察儿童智力水平。采用多因素线性回归模型分析孕前父亲烟草暴露对6岁儿童智力水平的影响。结果调整协变量后,孕前父亲烟草暴露使儿童总智商下降2.83分(95%CI:-5.51~-0.16),其中孕前父亲吸烟的效应值(OR=3.15,95%CI:-6.32~0.03)略高于孕前父亲二手烟暴露(OR=2.62,95%CI:-5.54~0.30)。孕前父亲吸烟对儿童总智商和知觉推理的影响呈剂量反应关系(趋势检验P<0.05),父亲每天吸烟5支以上的儿童,总智商下降6.57分(95%CI:-10.88~-2.26),知觉推理下降5.83分(95%CI:-10.61~-1.05)。此外,儿童性别和胎龄与孕前父亲烟草暴露在对儿童智商的影响中表现出显著的交互作用(P<0.05),即父亲烟草暴露对女童、胎龄<39周的儿童的智力影响更强。结论本研究发现孕前3个月父亲的烟草暴露与6岁儿童智力水平的下降有关,提示孕前健康指导应加强对备孕期间丈夫控烟的宣传,倡导夫妻双方共同承担起优生优育的责任。Objective To explore the effect of paternal exposure to cigarette smoke prior to pregnancy on children′s intelligence at 6years old,so as to provide epidemiological evidence for prenatal and postnatal care services.Methods A total of 530mother-child pairs were included in this study from the Shanghai-Minhang Birth Cohort Study(S-MBCS)established in 2012.Information on paternal exposure to cigarette smoke 3months prior to pregnancy was obtained through a structured questionnaire at the first antenatal checkup.Intelligence of children at 6years old was assessed using the Simplified Chinese Version of(the Wechsler Intelligence Scale for Children,Fourth Edition,WISC-Ⅳ).Multivariate linear regression model was used to analyze the effect of paternal cigarette smoke exposure prior to pregnancy on children′s intelligence at 6years old.Results After adjusting for covariates,paternal exposure to cigarette smoke prior to pregnancy was associated with a decrease of 2.83points(95%CI:-5.51to-0.16)of children′s Full-Scale Intelligence Quotient(FSIQ).The effect of paternal smoking(OR=3.15,95%CI:-6.32to 0.03)was slightly stronger than that of paternal exposure to second-hand smoking(OR=2.62,95%CI:-5.54to 0.30).The effect of paternal smoking prior to pregnancy on children′s FSIQ and Perceptual Reasoning Index(PRI)showed statistically significant dose-effect relationships(P_(fortrend)<0.05).Children whose fathers smoked more than 5cigarettes per day prior to pregnancy had a FSIQ decrease of 6.57points(95%CI:-10.88to-2.26)and a PRI decrease of 5.83points(95%CI:-10.61to-1.05).Besides,the sex and gestational weeks of children showed significant interactions with paternal exposure to cigarette smoke prior to pregnancy in the effects on children′s intelligence(P_(for interaction)<0.05).The effects of paternal exposure to cigarette smoke prior to pregnancy on the intelligence of girls,or of children with less than 39gestational weeks,were stronger.Conclusions Paternal exposure to cigarette smoke 3 months prior to pregnancy wa

关 键 词：孕前 父亲烟草暴露 儿童智力 队列研究 

分 类 号：R179[医药卫生—妇幼卫生保健]