食管癌患者血清细胞因子和免疫球蛋白水平的动态观察  

A dynamic observation on serum cytokine and immunoglobulin(IgG,IgA,IgM)in patients with esophagea cancer

作　　者：唐任光[1] 袁锡华[1] 唐甜甜[2] 唐习强[3] 黄艳青[3] 覃后继[3] 陈宏明[3] 方文珠[4] 龙显科[1] TANG Ren-guang;YUAN Xi-hua;TANG Tian-tian;TANG Xi-qiang;HANG Yan-qing;QIN Hou-ji;CHEN Hong-ming;FANG Wen-zhu;LONG Xian-Ke(Depatment of Clinial Laboratory Center,The Afliaed Hospital of Medical College of Yovjiang for Natinality,Baise 5300,China;不详)

机构地区：[1]右江民族医学院附属医院检验中心,百色533000 [2]右江民族医学院附属医院病案科,百色533000 [3]右江民族医学院附属医院胸外科,百色533000 [4]右江民族医学院附属医院核医学科,百色533000

出　　处：《中华预防医学杂志》2007年第S01期35-38,共4页Chinese Journal of Preventive Medicine

基　　金：广西教育厅立项自筹项目(200626216);右江民族医学院立项课题(059909);广西卫生厅科研项目(Z2006296)

摘　　要：目的研究白细胞介素-2(IL-2)、白细胞介素-8(IL-8)及免疫球蛋白(IgG、IgA、IgM)在食管癌患者血清中的水平变化,并探讨IL-2、IL-8、IgG、IgA、IgM水平在食管肿瘤临床分期之间的相关关系.方法用酶联免疫吸附试验(ELISA)方法检测了72例食管癌早期(Ⅰ-Ⅱ)患者、68例食管癌晚期(Ⅲ-Ⅳ)患者和120例对照者血清IL-2、IL-8水平,同时对食管癌患者血清免疫球蛋白IgG、IgA、IgM指标进行动态观察.结果血清IL-2水平食管癌早期患者组[(1.69±0.53)ng/m1]和食管癌晚期组患者[(1.11±0.60)ng/m1]显著低于正常对照组[(2.78±0.51)ng/m1](P<0.01),晚期患者较早期明显降低(P<0.05);血清IL-8水平食管癌早期患者组[(85.48±6.14)ng/L]和食管癌晚期患者组[(121.41±6.22)ng/L]均显著高于正常对照组[(54.48±12.20)ng/L](P<0.01),晚期患者较早期升高(P<0.01);食管癌患者血清IL-2及IL-8水平与肿瘤的恶性化程度有明显相关性.而食管癌患者IgG[(12.23±2.50)g/L]、IgM[(1.60±0.80)g/L]含量与正常对照组IgG[(11.65±3.70)g/L]、IgM[(1.46±0.71)g/L]比较差异无统计学意义(P>0.05),IgA的含量[(3.50±1.10)g/L]与正常对照组[(1.88±1.08)g/L]比较差异有统计学意义(P<0.01),且随病情的恶化程度IgA水平的变化有增高趋势.结论IL-8在食管癌发病过程中可能起着促进作用,而IL-2可能起着抑制作用,IgA在食管癌病人中呈正相关;三者的免疫失调状态可能与食管癌密切相关;IL-2、IL-8、IgA水平可作为食管癌病情监测的指标,同时对肿瘤的临床分期、疗效和预后的判断也有一定的帮助.Objective To study the changes of serum interleukin-2(L-2),interleukin-8(IL-8)and immunoglobulin(IgG、IgA、IgM)in patients with esophageal cancer,and to probe the relationship between the levels of IL-2 JL-8、IgG IgA and IgM and the progress of cancer.Methods The serum levels of IL-2 and IL-8 were detected by enzyme linked immunosorbent assay for 72 case of primary esophageal cancer,68 advanced esophageal cancer and 120 healthy controls,and the level of inmunoglobulin(IgG、IgA、gM)in patients with esophageal cancer was dyamically observed.Results The IL2 level in patients with early esophageal cancer[(1.69±0.53)ng/ml]or late esophageal cancer[(1.11±0.60)ng/ml]was lower than the control group[(2.78±0.51)ng/ml](P<0.01),the late esophageal cancer group was lower than early esophageal cancer group(P<0.05).The level of IL-8 in patients with early esophageal cancer[(85.48±6.14)ng/L]or late lesophageal cancer[(121.41±6.22)ng/L]was much higher than the control group[(54.48±12.20)ng/L](P<0.01),the late esophageal cancer grope was much higher than early esophageal cancer grope(P<0.01);There was crelaion between the levels of IL-2 and IL8 and the worsen extent of the tumour in patients with early esophageal cancer or late esophageal cancer.But the level of IgG[(12.23±2.50)g/L],IgM[(1.60±0.80)g/L]in the patients with esophageal cancer compared with the level of IgG([(11.65±3.70)g/L],IgM[(1.46±0.71)g/L]in the health control gope have no sgifcant dference(P>0.05),the level of IgA[(3.50±1.10)g/L]in patients with esophageal cancer Compared with the control group[(1.88±1.08)g/L]has significant dfference(P<0.01),and along with the worsen-extent of the tumor in patients the level of IgA has the increased tendency.Conctusion The IL 8 might accelerate the pathogenesis of esophageal cancer,and the IL-2 might restrain.The positive correlation between the level of IgA and the patients with esophageal cancer is observed in this study;the immune maladjustment of IL-2、IL-8 and IgA might be correlative to esopbageal cance

关 键 词：食管肿瘤 白细胞介素-2 白细胞介素-8 免疫球蛋白类 

分 类 号：R73[医药卫生—肿瘤]