倍频视野计对视野前期开角型青光眼视野进展的风险预测——8年随访研究  

Potential of Frequency-Doubling Technology Perimetry for Predicting the Risk of Future Visual Field Loss on Standard Automated Perimetry for Preperimetric Open-Angle Glaucoma The Outcome of 8-year-follow-up

作　　者：范翔[1] 吴玲玲[1] 杨帆[1] 肖格格[1] 刘峰[1] FAN Xiang;WU Lingling;YANG Fan;XIAO Gege;LIU Feng(Department of Ophthalmology,Peking University Third Hospital,Beijing Key Laboratory of Restoration of Damaged Ocular Nerve,Beijing 100191,China)

机构地区：[1]北京大学第三医院眼科眼部神经损伤的重建保护与康复北京市重点实验室,北京100191

出　　处：《中国实用眼科杂志》2018年第1期36-41,共6页Chinese Journal of Practical Ophthalmology

摘　　要：目的探索倍频视野检查法(frequency-doubling technology perimetry,FDP)对视野前期开角型青光眼(open-angle glaucoma,OAG)在将来标准自动视野检查法(standard automated perimetry,SAP)上出现视野异常的风险预测能力.方法前瞻性队列研究.对单眼SAP视野异常(Octopus,G2程序)OAG患者视野正常眼进行基线FDP-N30程序检测,将FDP的19个刺激区匹配至SAP视野的53个测试点,之后连续8年SAP视野随访,最终计算FDP刺激区的异常转化为将来SAP相应区域视野异常的相对危险度(relative risk,RR).结果48例患者完成了8年随访.基线时,912个FDP刺激区中有21%(196/912)检测出异常,其中26%(51/196)的异常刺激区在4~90个月转化为SAP相应区域的视野异常.FDP刺激区的异常转化为将来SAP相应区域异常的RR为5.50(95%置信区间3.53~8.58,p<0.001).结论在视野前期OAG中,FDP可以在一定程度上对将来SAP视野的异常进行准确的风险预测.Objective To explore the potential of frequency-doubling technology perimetry(FDP)for predicting the risk of future visual field loss on standard automated perimetry(SAP)for preperimetric openangle glaucoma(OAG).Methods A prospective cohort study.OAG patients with unilateral field loss detected by SAP(Octopus,G2 program)were examined with the FDP N-30 threshold program(Humphrey Instruments)at baseline.53 of the SAP test points were matched to the 19 of FDP sectors as SAP-on-FDP sectors.Visual field examinations were followed by a series of SAP examinations for the perimetrically normal eyes administered over 8 years.The relative risk(RR)of subsequent SAP abnormality corresponding to FDP abnormal sectors in perimetrically normal eyes of participants at baseline was calculated finally.Results Forty-eight perimetrically normal eyes of 48 participants had complete data and a qualifying follow-up.At baseline,there were 912 FDP sectors in the 48 eyes with normal SAP results,from which 21%(196/912)were abnormal.During the 8-year-follow-up,26%(51/196)for FDP abnormal sectors developed an SAP abnormality in the SAP-on-FDP sector in 4 to 90 months after baseline,and the RR of subsequent SAP abnormality corresponding to abnormal FDP sectors was 5.50(95%confidence interval,3.53~8.58;P<0.001).Conclusions In preperimetric OAG,FDP could exactly predict the risk of future visual field loss on SAP to some extent.

关 键 词：倍频视野计 视野前期开角型青光眼 标准自动视野计 前瞻性研究 相对危险度 

分 类 号：R775[医药卫生—眼科]