VEGF、HIF-1α、COX-2与慢性糜烂性胃炎的关系  

Relationship between VEGF, HIF-1 α, COX-2 and Chronic Erosive Gastritis

作　　者：梅凯雁 李军茹[2] 龚自坤 MEI Kai-yan;LI Jun-ru;GONG Zi-kun(Qinghai University,Xining Qinghai;Qinghai Provincial Hospital of traditional Chinese medicine,Xining Qinghai)

机构地区：[1]青海大学,青海西宁 [2]青海省中医院,青海西宁

出　　处：《世界最新医学信息文摘》2020年第41期60-61,64,共3页World Latest Medicine Information Electronic Version

摘　　要：慢性糜烂性胃炎是以胃黏膜出现或隆起或平坦的糜烂面为主要特征的胃黏膜损害性病变。此病临床多常见,可或多或少影响人们工作和生活,更有甚者,可引起出血、穿孔、癌变等恶劣结果,严重危害人类生命健康。且该病发病率高、病情迁延且发病机理尚不十分明确,使得当今临床对该病治疗效果及预后不慎令人满意。笔者现根据近20年慢性糜烂性胃炎的相关文献,整理总结出VEGF、HIF-1α、COX-2与慢性糜烂性胃炎的相关报道,以期探索上述因子参与该病时的作用机制,帮助人们更全面认识、更好地防治该病,以及为临床治疗及巩固疗效做出贡献。Chronic erosive gastritis is a damaging lesion of gastric mucosa characterized by protuberance or flat erosive surface of gastric mucosa.The disease is more common in clinic,which can more or less affect people's work and life,and what is more,it can cause bleeding,perforation,canceration and other adverse results,seriously endangering human life and health.And the incidence of the disease is high,the disease is prolonged and the pathogenesis is not very clear,which makes the clinical treatment effect and prognosis of the disease inadvertently satisfactory.According to the relevant literature of chronic erosive gastritis in the past 20 years,the author collates and summarizes the related reports of HIF-1α,VEGF,COX-2 and chronic erosive gastritis,in order to explore the mechanism of the above-mentioned factors participating in the disease,help people to fully understand and better prevent and treat the disease,and contribute to clinical treatment and consolidation of curative effect.

关 键 词：慢性糜烂性胃炎 血管内皮生长因子 缺氧诱导因子-1 环氧合酶-2 

分 类 号：R573.3[医药卫生—消化系统]