Management of early-onset sepsis in a teaching hospital: A descriptive retrospective study  

作　　者：Sana H.Mohamed Rasha R.Binni Bashir A.Yousef 

机构地区：[1]Department of Clinical Pharmacy,Faculty of Pharmacy,University of Khartoum,Al-Qasr Ave,Khartoum 11111,Sudan [2]Department of Pharmacology,Faculty of Pharmacy,Sudan International University,Ebid-Khatim Street,Khartoum 11111,Sudan [3]Department of Pharmacology,Faculty of Pharmacy,University of Khartoum,Al-Qasr Ave,Khartoum 11111,Sudan

出　　处：《Journal of Acute Disease》2020年第2期78-82,共5页急性病杂志（英文版）

摘　　要：Objective: To evaluate the management of early-onset sepsis at Saad Abul-Ella Teaching Hospital, Sudan. Methods: A descriptive retrospective hospital-based study was carried out at the Nursery Department of Saad Abul-Ella Teaching Hospital. All medical records of neonates with suspected or confirmed sepsis during the year 2017 were reviewed to evaluate the management of antibiotics for sepsis using a data collection form. Results: Out of the 205 cases, 82 neonates (40%) were diagnosed as early-onset sepsis, among which the majority was male (68%). All neonates were given cefotaxime plus vancomycin as empirical therapy which was changed to other antibiotics in 23% of the cases. The common risk factors associated with early-onset sepsis wereprolonged rupture of membrane (41.8%), preterm delivery (26.3%) and low birth weight (15.1%). Blood cultures were performed in 168 cases, and 19% had bacterial growth of Staphylococcus aureus which is the most common isolated pathogen. Conclusions: Cefotaxime plus vancomycin are the main empirical antibiotic for sepsis, and Staphylococcus aureus is the most common pathogen associated with early-onset sepsis.

关 键 词：UMBELLIFERONE Type 2 diabetes mellitus Oxidative stress INFLAMMATION Glycation 

分 类 号：H31[语言文字—英语]