腹主动脉瘤患者血清HIF-1α浓度的临床意义  

作　　者：徐妙军[1] 黄洪亮[1] 王国华[1] 唐黎明[1] 

机构地区：[1]浙江省绍兴市人民医院(浙江大学绍兴医院),312000

出　　处：《浙江临床医学》2019年第4期442-443,共2页Zhejiang Clinical Medical Journal

基　　金：浙江省医药卫生科研基金项目(2017KY665);绍兴市科技计划项目(2018C30054);绍兴市人民医院青年基金项目(2017A05).

摘　　要：目的 通过分析腹主动脉瘤患者的缺氧诱导因子-1α(HIF-1α)血清浓度,探讨其在早期诊断和病情评估的临床意义.方法 回顾性分析自2015年6月至2018年5月被诊断为腹主动脉瘤的132例患者,根据动脉瘤的严重程度,分为早期组(n=42)、中期组(n=44)和晚期组(n=46).酶联免疫测定法(ELISA)测定各组间的HIF-1α浓度并对比.结果 早期组的HIF-1α(t=27.34,P<0.05)血清浓度比对照组的显著性增高;中期组的HIF-1α(t=33.27,P<0.05)血清浓度比早期组的显著性增高;晚期组的HIF-1α(t=24.59,P<0.05)血清浓度比中期组的显著性增高.结论 血清HIF-1α浓度在腹主动脉瘤早期诊断和严重程度评估上具有一定的临床价值.Objective To investigate serum concentration of hypoxia inducible factor-1α(HIF-1α)in patients with aneurysms at different stages,and to determine critical role in early diagnosis and evaluation of severity.Methods The serum concentration of HIF-1αin 132 cases of patients diagnosed as aneurysms during Jun 2015 to May 2018 in our hospital were retrospectively analyzed which detected by Enzyme-linked immunosorbent assays(ELISA).According to severity of aneurysms patients were divided into early stage group(n=42),mid-term group(n=44),and late stage group(n=46)Serum level of HIF-1αwas compared among different groups.Results Serum concentrations of HIF-1α(t=27.34,P<0.05)in early stage group was significantly higher than that in normal group.Serum concentrations of HIF-1α(t=33.27,P<0.05)in the mid-term group was significantly higher than that in the early stage group.Serum concentrations of HIF-1α(t=24.59,P<0.05)in the late stage group was significantly higher than that in the mid-term group.Conclusion Serum concentration of HIF-1αhas clinical value of early diagnosis and assessment of disease severity.

关 键 词：动脉瘤 缺氧诱导因子 诊断 

分 类 号：R73[医药卫生—肿瘤]