放疗和多西他赛分别联合卡培他滨治疗乳腺癌脑转移的临床观察  

Clinical Observation of Radiotherapy and Docetaxel Combined with Capecitabine in the Treatment of Breast Cancer with Brain Metastases

作　　者：常庆龙[1] 杨红星[1] 贾国丛[1] 翟保平[2] Chang Qing-long;Yang Hong-xing;Jia Guo-cong;Zhai Bao-ping(DepartmentⅡof Mammary Gland,the Third Affiliated Hospital of Zhengzhou University,Zhengzhou Henan 450052,ChinaDepartment of Mammary Gland,Henan Provincial People’s Hospital,Zhengzhou Henan 450000,China)

机构地区：[1]郑州大学第三附属医院乳腺二科,河南郑州450052 [2]河南省人民医院乳腺科,河南郑州450000

出　　处：《中国合理用药探索》2019年第3期8-11,共4页Chinese Journal of Rational Drug Use

基　　金：河南省医学科技攻关计划项目(201601013)

摘　　要：目的:探讨放疗和多西他赛分别与卡培他滨联合治疗乳腺癌脑转移的临床效果。方法:选取我院2012年1月—2015年1月收治的42例女性乳腺癌脑转移患者为研究对象,以随机数字表法分为对照组和试验组,各21例。对照组采用多西他赛(75 mg/m^2,第一天静滴)联合卡培他滨(1 900 mg/m^2,bid,po,连服14天,停药7天)方案治疗,试验组采用卡培他滨(用法用量同对照组)同步放疗方案,比较两种治疗方案的临床疗效、1年存活率、毒副作用及生活质量。结果:试验组总有效率(85.71%)高于对照组(47.62%),差异有统计学意义(P <0.05);试验组1年存活率高于对照组,差异有统计学意义(P <0.05);试验组生活质量提高率高于对照组,差异有统计学意义(P <0.05);两组毒副反应发生情况比较,差异无统计学意义(P> 0.05)。结论:放疗联合卡培他滨治疗乳腺癌脑转移的效果优于多西他赛联合卡培他滨化疗方案,可更有效改善生活质量,值得推广。Objective:To investigate the clinical effect of radiotherapy and docetaxel combined with capecitabine in the treatment of breast cancer with brain metastases.Methods:42 female patients with breast cancer with brain metastases from January 2012 to January 2015 were selected as subjects investigated and randomly divided into a control group and an experimental group,21 cases each.The patients in the control group were treated with docetaxel(75 mg/m2,intravenous infusion on the first day)in combination with capecitabine(1 900 mg/m2,bid,po,continuous medication for 14 days,no treatment for 7 days),and the patients in the experimental group were given synchronous radiotherapy with capecitabine(the dosage and usage were same as those in the control group).The clinical efficacy of the two treatment schemes,1-year survival rate,toxicity and other side effects and quality of life were compared between the two groups.Results:The total effective rate in the experimental group(85.71%)was higher than that in the control group(47.62%),and the difference was statistically significant(P<0.05).The 1-year survival rate in the experimental group was higher than that in the control group,and the difference was statistically significant(P<0.05).The improvement rate of quality of life in the experimental group was higher than that in the control group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in the incidence of toxicity and other side effects(P>0.05).Conclusion:Radiotherapy combined with capecitabine is superior to docetaxel plus capecitabine in the treatment of breast cancer,which can improve the quality of life and is worth promoting.

关 键 词：放疗 多西他赛 卡培他滨 乳腺癌 脑转移 临床观察 

分 类 号：R73[医药卫生—肿瘤]