高压氧配合依达拉奉、丹参川芎嗪和奥扎格雷钠治疗急性脑梗塞的临床疗效  

Clinical Efficacy of Hyperbaric Oxygen Combined with Edaravone, Salvia Miltiorrhiza Ligustrazine and Ozagrel Sodium in the Treatment of Acute Cerebral Infarction

作　　者：李琼[1] 臧卫平[1] 封倩[1] 张志军[1] 冯来会[1] 臧文举[1] Li Qiong;Zang Wei-ping;Feng Qian;Zhang Zhi-jun;Feng Lai-hui;Yan Wen-ju(Department of Neurology,Zhengzhou People’s Hospital,Zhengzhou,Henan 450000,China)

机构地区：[1]郑州人民医院神经内科,河南郑州450000

出　　处：《中国合理用药探索》2019年第1期75-78,共4页Chinese Journal of Rational Drug Use

摘　　要：目的 :探讨奥扎格雷钠、丹参川芎嗪、依达拉奉联合高压氧治疗急性脑梗塞的疗效及对患者血清炎症因子的影响。方法 :选取2015年3月—2017年1月我院收治的92例急性脑梗塞患者,按随机数字表法分为对照组与研究组,各46例。对照组采取奥扎格雷钠(120 mg,qd)+丹参川芎嗪(10 mL,qd)+依达拉奉(30 mg,qd)治疗,研究组于对照组基础上采取高压氧治疗,两组均治疗1个月。比较两组美国国立卫生研究院脑卒中量表(NIHSS)、临床疗效、血清高敏C反应蛋白(hs-CRP)、可溶性细胞间黏附分子(s ICAM)-1水平、不良反应发生情况。结果:治疗后两组NIHSS分值较治疗前降低,且研究组低于对照组,差异有统计学意义(P <0.05);研究组总有效率高于对照组,差异有统计学意义(P <0.05);治疗后两组血清hs-CRP、s ICAM-1水平低于治疗前,且研究组低于对照组,差异有统计学意义(P <0.05);两组不良反应发生率比较,差异无统计学意义(P> 0.05)。结论 :奥扎格雷钠+丹参川芎嗪+依达拉奉联合高压氧治疗急性脑梗塞的疗效显著,可恢复神经功能,降低血清炎症因子水平,且安全性较高。Objective:To investigate the efficacy of ozagrel sodium,Salvia miltiorrhiza ligustrazine and edaravone combined with hyperbaric oxygen in the treatment of acute cerebral infarction and their effect on serum inflammatory factors.Methods:92 patients with acute cerebral infarction admitted to our hospital from March 2015 to January 2017 were selected and divided into a control group and a study group according to the random number table method,46 cases in each group.The patients in the control group were treated with ozagrel sodium(120 mg,qd)+Salvia miltiorrhiza ligustrazine(10 mL,qd)+edaravone(30 mg,qd),and the patients in the study group were treated with hyperbaric oxygen on the basis of the control group.All patients were treated for one month.The levels of National Institute of Health Stroke Scale(NIHSS),clinical effcacy,serum high-sensitivity C-reactive protein(hs-CRP)and soluble intercellular adhesion molecule(sICAM)-1,and adverse reactions were compared between the two groups.Results:The scores of NIHSS in the two groups after treatment were lower than those before treatment,and the scores in the study group were lower than those in the control group,with statistically significant difference(P<0.05).The total effective rate in the study group was higher than that in the control group,with statistically significant difference(P<0.05).The levels of serum hs-CRP and sICAM-1 in the two groups after treatment were lower than those before treatment,and the levels in the study group were lower than those in the control group,with statistically significant differences(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P<0.05).Conclusion:Ozagrel sodium,Salvia miltiorrhiza ligustrazine and edaravone combined with hyperbaric oxygen are effective in the treatment of acute cerebral infarction,which can restore nerve functions and reduce serum inflammatory factor levels,and have high safety.

关 键 词：高压氧 依达拉奉 丹参川芎嗪 奥扎格雷钠 急性脑梗塞 

分 类 号：R743[医药卫生—神经病学与精神病学]