干细胞标志Nanog在食管鳞癌组织中表达及预后关系  

Expression and Clinical Significances of Nanog in Esophagea Squamous Carcinoma

作　　者：麻成方[1] 余征[2] 李绍鹏[1] 李志华[1] 魏春勇[1] 汪礼旭[1] 洪琼川[1] MA Cheng-fang;YU Zheng;LI Shao-peng;LI Zhi-hua;WEI Chun-yong;WANG Li-xu;HONG Qiong-chuan(Department of Cardiothoracic Surgery,Longgang District Central Hospital of Shenzhen,Shenzhen 518116,Guangdong,China;Department of Physical Examination,People Hospital of Shenzhen Longgang District,Shenzhen 518116,Guangdong,China)

机构地区：[1]深圳市龙岗中心医院(深圳市第九人民医院)心胸外科,广东深圳518116 [2]深圳市龙岗区人民医院体检科,广东深圳518116

出　　处：《医学信息（医学与计算机应用）》2016年第34期31-32,共2页Medical Information

基　　金：深圳市龙岗区科技计划项目(编号YS2013131)。

摘　　要：目的:探讨食管鳞癌组织中干细胞标志Nanog表达及其与肿瘤病理特征和预后的关系。方法采用免疫组化方法测定60例食管鳞癌组织和10例癌旁组织中干细胞标志Nanog的表达情况,比较它在组织中的表达差异,及其与食管癌相关临床病理特征和预后的关系。结果在60例患者中,26例出现复发转移,Nanog在转移组中表达率分别为61.5%(16/26),在非转移组中分别为26.5%(9/34),差异有统计学意义,值<0.05。食管鳞癌原发灶分化程度不同,Nanog表达存在差异,但是同T和N分期没有明显的相关性(>0.05)。Nanog为阳性表达其转移率显著高于为阴性表达者。结论食管鳞癌组织中Nanog表达与患者术后复发转移有一定关系,该检测有助于预后的评价。Objective To investigate the expression of Nanog in esophageal squamous carcinoma and their correlations with the pathologic parameter of cancer and prognosis.Methods The expression of Nanog in 60 surgical specimens of esophageal squamous carcinoma and 10 paracarcinoma tissues was detected by immunohistochemistry method.The correlations between the expression of Nanog and the clinical pathological characteristics were analyzed statistically.Results Relapse and metastasis of 26 cases was detected in all patients.In metastasis group,the positive expression rate of Nanog was 61.5%(16/26)).And the positive expression rate of Nanog in non-metastasis group was 26.5%(9/34).The difference was signigicant(<0.05).Expression of Nanog signigicantly correlated with differentiation,but was not associated with T stage or N stage.Metastatic rate in positive expression was higher than in negative expression.Conclusion The expression of Nanog related with progression and prognosis of esophageal squamous carcinoma,they are both hopeful predictors for patients with esophageal squamous carcinoma.

关 键 词：食管鳞癌 NANOG 

分 类 号：R73[医药卫生—肿瘤]